Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior |
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Authors: | LinLin Li YanQi Zhang NanJing Hao Dong Chen FangQiong Tang |
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Institution: | 1. Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China
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Abstract: | Silica nanorattle with hollow and mesoporous structure has been proven to be an excellent drug carrier. However, how to control the drug release from silica nanorattle is still a challenge. In this study, we designed two methods, in-situ polymerization method and water in oil in water (W/O/W) double emulsion method, to coat a nanosized poly(lactic-co-glycolic acid) (PLGA) layer onto the surface of silica nanorattle for controlling the drug release behavior. Hydrophobic antitumor drug docetaxel was loaded into the PLGA coated silica nanorattle (PLGA@SN). The drug release profile, cellular uptake and cytotoxicity on human liver cancer HepG2 cells were evaluated to prove that the PLGA layer plays an effective role in tuning the drug delivery. |
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Keywords: | silica nanorattle PLGA microemulsion in-situ copolymerization docetaxel drug delivery |
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