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Isolation and identification of a novel STR (D17S2204) in the vicinity of NF1 locus |
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| Authors: | Xiyuan Sun Long Yu Qiping Zheng Yurong Xin Liemin Zhou Yuxin Fan Ying Jiang Jiahui Xia Zhuolin Liu Shouyuan Zhao |
| Institution: | SUN Xiyuan, YU Long, ZHENG Qiping, XIN Yurong, ZHOU Liemin, FAN Yuxin, JIANG Ying, XIA Jiahui, LIU Zhuolin and ZHAO Shouyuan State Key Laboratory of Genetic Engineering , Institute of Genetics , Fudan University , Shanghai 200433 , China ; Department of Neurology, The First Affiliated Hospital, Sun Yatsen University of Medical Sciences, Guangzhou 510089, China State Key Laboratory of Medical Genetics , Hunan Medical University, Changsha 410078, China |
| Abstract: | Using a synthetic oligonucleotide (dA-dC)15 as a probe to screen a probe pool made by microdissected human chromosome band 17q11-q12, a DNA fragment containing (CA)16 was isolated, which is a novel short tandem repeat (STR) determined by searching in the GenBank and GDB. It has 8 allelic types with a PIC value of 0.61. The novel STR is conformed with Mendelian segregation according to the linkage analysis of a three-generation neurofibromatosis type I (NF1) pedigree. The STR was localized at chromosome band 17q11-q12 in the vicinity of NFl gene by FISH analysis. The accession number of the STR in GenBank and GDB is G32112 and Dl752204 respectively. |
| Keywords: | chromosome 17q11-q12 short tandem repeats (STR) D17S2204 neurofibromatosis type Ⅰ (NF1) |
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