Why endophenotype development requires families |
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Authors: | GLAHN David C & BLANGERO John |
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Institution: | GLAHN David C 1,2* & BLANGERO John 3 1 Department of Psychiatry,Yale University School of Medicine,New Haven,CT 06511,USA,2 Olin Neuropsychiatry Research Center,Institute of Living,Hartford Hospital,CT 06106,3 Department of Genetics,Texas Biomedical Research Institute,San Antonio,TX 78227 |
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Abstract: | Endophenotypes are heritable quantitative traits that are associated with disease liability, can be measured in both affected and unaffected individuals, and provide much greater power to localize and identify risk genes for mental illness than does affection status alone. Traditionally, endophenotypic markers for psychiatric illnesses include in vivo neuroanatomic and functional magnetic resonance imaging measurements and indices of neurocognitive abilities. However, neurocognitive and neuroimaging measure... |
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Keywords: | endophenotype family studies biomarker schizophrenia bipolar disorder |
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