Effects ofPKCα antisense RNA on human breast cancer cell proliferation and expression ofcyclinD1 andCDK4 |
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Authors: | Jianli Sang Yongchao Wang |
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Institution: | (1) Laboratory of Cell Biology, Department of Biology, Beijing Normal University, 100875 Beijing, China |
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Abstract: | The role of PKCα in human breast cancer cell proliferation and expression ofcyclinD1 andCDK4 has been investigated using inhibition ofPKCα expression by its antisense RNA. WhenPKCα expression was inhibited the rate of cell proliferation decreased apparently and the levels ofcyclinD1 andCDK4 mRNA were lower than the control. The results showed thatPKCα, a key member of signal transduction system, played an important role in human breast cancer cell proliferation and had a
close relationship with expression ofcyclinD1 andCDK4 which control start of cell cycle. |
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Keywords: | breast cancer PKCα cell proliferation cyclinD1 CDK4 |
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