Corticofugal modulation of frequency tuning of inferior collicular neurons in big brown bat,Eptesicus fuscus |
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Authors: | Jiping Zhang Xinde Sun Philip H S Jen |
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Institution: | (1) Department of Biology, East China Normal University, 200062 Shanghai, China;(2) Division of Biological Sciences, University of Missouri-Columbia, 65211 MO, USA |
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Abstract: | In order to explore the possible mechanism of corticofugal modulation of excitatory frequency tuning curves (EFTCs) of midbrain
neurons, we examined the change of sharpness, frequency-intensity response area, minimum threshold of both EFTCs and inhibitory
frequency tuning curves (IFTCs) of inferior collicular neurons during corticofugal modulation using two-tone inhibition paradigm
and micro-electrical stimulation technique. Our data showed that corticofugal inhibition increased sharpness, minimum threshold,
and decreased the frequency-intensity response area of EFTCs, at the same time it decreased the sharpness, minimum threshold
but increased the frequency-intensity response area of IFTCs. The opposite results were observed for EFTCs and IFTCs of corticofugally
facilitated inferior collicular neurons. During corticofugal inhibition, the percent change of frequency-intensity response
area of EFTCs had significant correlation with the percent change of that of IFTCs. These data suggest that cortical neurons
are likely to improve frequency information processing of inferior collicular neurons by modulation of IFTCs. |
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Keywords: | bat auditory cortex inferior colliculus frequency tuning modulation |
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