| 过氧化氢／醋酸体系降解壳聚糖及其产物的抗菌活性研究 |
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| 引用本文： | 覃彩芹,杜予民,刘义,肖玲.过氧化氢／醋酸体系降解壳聚糖及其产物的抗菌活性研究[J].孝感学院学报,2001,21(6):9-13. |
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| 作者姓名： | 覃彩芹 杜予民 刘义 肖玲 |
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| 作者单位： | 1. 孝感学院,化学系,湖北,孝感,432100
2. 武汉大学化学与环境科学学院,湖北,武汉,430072 |
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| 摘 要： | 用过氧化氢／醋酸体系降解壳聚糖制备不同分子量的甲壳低聚糖，这些样品用凝胶渗透色谱（GPC），碳－13核磁共振谱（^13C－NMR）分析表征。降解所得壳聚糖产物中有羧基生成，且随着分子量的降低，羧基含理增加。用微热量法来测量降解壳聚糖对金葡萄球菌的抑菌作用，同时用平板法测水溶性壳聚糖抑制多种细菌的活性，结果表明2％浓度水溶性产物可以完全抑制这些细菌的生长。
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| 关 键 词： | 壳聚糖 过氧化氢 降解 微热量法 抗菌活性 醋酸 |
| 文章编号： | 1671-2544(2001)06-0009-05 |
Antibacterial Activity of Degraded Chitosan by H2O2/HAc |
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| QIN Cai-qin ,DU Yu-min ,LIU Yi ,XIAO Ling.Antibacterial Activity of Degraded Chitosan by H2O2/HAc[J].JOURNAL OF XIAOGAN UNIVERSITY,2001,21(6):9-13. |
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| Authors: | QIN Cai-qin DU Yu-min LIU Yi XIAO Ling |
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| Institution: | QIN Cai-qin 1,DU Yu-min 2,LIU Yi 2,XIAO Ling 2 |
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| Abstract: | Chitosans with low molecular weight were prepared by H 2O 2/HAc,and characterized by gel permeation chromatography and 13 C-NMR.Their carboxylic contents increased with decrease in molecular weight (Mw) . Microcalorimetry was firstly used to study the kinetics of action of the chitosans on a strain of S.aureus at pH 7.The antibacterial activity of the water-soluble chitosan was also evaluated by the conventional agar plate method at pH 7.Less than 2% concentration of the water-soluble product could completely inhibit the growth of these bacteria. |
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| Keywords: | chitosan degradation hydrogen peroxide microcalorimetry antibacterial activity |
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