一种中西药复配消毒抑菌剂的消毒抑菌效果、毒性和稳定性

研究一种中西药复配消毒抑菌剂的消毒抑菌效果、毒性和稳定性.采用悬液定量杀菌试验、病毒悬液定量试验、动物毒性试验和稳定性试验对该中西药复配消毒抑菌剂的消毒抑菌效果及相关性能进行考察.试验结果表明:用该消毒抑菌剂原液对悬液内金黄色葡萄球菌和大肠杆菌作用1 min,平均杀灭对数值均大于5,对悬液内白色念珠菌作用1 min,平均杀灭对数值大于4,对HCoV-NL63病毒和H9N2亚型禽流感病毒作用2 min,平均灭活对数值均大于5;试验动物的经口半数致死量(LD₅₀)>5 000 mg·kg^-1且皮肤刺激反应平均指数为0;将该复配消毒抑菌剂密封包装,于-20 ℃下放置7 d,其性状仍保持澄清透明,于37 ℃存放90 d后,其杀菌效果与存放前基本一致.

Disinfection and Antibacterial Effect,Toxicity and Stability of a Chinese and Western Medicine Compound Disinfectant and Antibacterial Agent

To study the disinfection and antibacterial effect, toxicity and stability of a Chinese and Western medicine compound disinfectant and antibacterial agent, suspension quantitative sterilization test, viral suspension quantitative test, animal toxicity test, and stability test were used to investigate the above performance of this compound agent. The results show that the average killing logarithm values were both greater than 5 when the disinfectant and bacteriostatic stock solution was used to kill Staphylococcus aureus and Escherichia coli in suspension for 1 min, and the values were greater than 4 for Candida albicans in suspension for 1 min, and greater than 5 for HCoV-NL63 virus and H9N2 subtype avian influenza virus treated for 2 min. The LD₅₀ of the test animals passing through the mouth is above 5 000 mg· kg^-1 and the average index of skin irritation response is 0. Seal the agent with the package and place it at -20 ℃ for 7 d, its symptoms remain clear and transparent. After storage at 37 ℃ for 90 d, the sterilization effect is basically the same as storage before.