大麻药生品和三种炮制品的急性毒性比较

为评价大麻药不同炮制品对小鼠的急性毒性反应,采用经典的急性毒性实验方法测定了生品、麸制品、姜制品和酒制品的小鼠口服半数致死量(LD50),观察小鼠急性毒性症状,记录其死亡率和体重变化.结果表明:大麻药生品和3种炮制品的LD50由大到小顺序为姜制品>麸制品>生品>酒制品,LD50值分别为17.93,16.77,12.11,9.45 g·kg-1.怠动、腹泻、心跳加速,唾液分泌增加是主要的急毒症状.故不同的炮制方法对大麻药的毒性影响较大,其毒性成分与中毒机理尚待进一步研究.

Comparative study on the acute toxicity of the raw Radix Dolichosae and 3 processed products

To evaluate the acute toxicity effects of the different processed products from Radix Dolichosae on mice, the mice were orally administrated the raw Radix Dolichosae, the products processed by bran, ginger and wine. The LD₅₀ value was determined by the classic methods and the acute toxic symptoms of mice were observed. The death rate and the weight changes of mice were also recorded. The results indicated that among the raw Radix Dolichosae and 3 processed products, the LD₅₀ values of the ginger processed product was the highest, then the bran processed product, the raw product ranked third, the wine processed product was the lowest. They are 17.93, 16.77, 12.11 and 9.45 g/kg, respectively. Hypokinesia, diarrhea, cardioacceleration and hypersalivation were the main acute toxicity symptoms. So it is conclude that the toxicity of Radix Dolichosae was significantly influenced by the different processing methods. Its toxic components and mechanisms remain further elucidate in the following study.