| Fe3+氧化-EDTA返滴定法测定卡托普利含量 |
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| 引用本文： | 成凤桂.Fe3+氧化-EDTA返滴定法测定卡托普利含量[J].中南民族大学学报(自然科学版),2006,25(2):28-30. |
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| 作者姓名： | 成凤桂 |
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| 作者单位： | 中南民族大学,化学与材料科学学院分析化学国家民委重点实验室,武汉,430074 |
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| 摘 要： | 应用Fe^3＋氧化-EDTA返滴定法测定了卡托普利的含量.探讨了反应温度,反应时间,酸度等对测定的影响.实验结果表明：卡托普利的平均测定含量为99.58%（RSD＜0.4%）,平均加标回收率为99.68%（RSD＜0.5%）.与药典法比较,测定值基本一致,而RSD小于药典法,可排除片剂中共存物的干扰.
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| 关 键 词： | 卡托普利 乙二胺四乙酸二钠 返滴定 Fe3 -氧化 |
| 文章编号： | 1672-4321（2006）02-0028-03 |
| 收稿时间： | 2006-01-16 |
| 修稿时间： | 2006年1月16日 |
Determinnation of the Captopril Content in Tablets by Fe3+ Oxidation-Back Titration with EDTA |
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| Cheng Fenggui.Determinnation of the Captopril Content in Tablets by Fe3+ Oxidation-Back Titration with EDTA[J].Journal of South-Central Univ for,2006,25(2):28-30. |
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| Authors: | Cheng Fenggui |
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| Institution: | Prof, College of Chemistry and Material Science, Key Laboratory for Analytical Chemistry of the State Ethnic Affairs Commission, SCUFN, Wuhan 430074, China |
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| Abstract: | The captopril tablets was determinated by Fe~(3+) oxidation-back titration with EDTA.The influence of reacting temperature,reacting time and pH was discussed.The results showed that average content of the captopril in tablets was 99.58%(RSD<0.4%) and that average recovery was 99.68%(RSD<0.5%) by determination with this method.In comparison with the pharmacopoeia method,the content of captopril was almost same by this method,but the RSD was smaller than that the pharmacopoeia method.The disturbance of concomitant matter in the captopril tablets was eliminated. |
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| Keywords: | captopril back titration EDTA Fe~(3+)-oxidation |
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