| 接枝聚合物PVA—g—PNIPA的合成 |
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| 引用本文： | 王俊卿,陈岚,苏致兴.接枝聚合物PVA—g—PNIPA的合成[J].兰州大学学报(自然科学版),2001,37(2):95-99. |
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| 作者姓名： | 王俊卿 陈岚 苏致兴 |
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| 作者单位： | 1. 兰州大学化学化工学院
2. 兰州医学院第一附属医院药剂科, |
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| 基金项目： | 甘肃省自然科学基金! (ZR- 97- 0 2 7)资助项目 |
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| 摘 要： | 采用自由基溶液聚合制备了具有温敏性的N-异丙基丙烯酸胺的线性均聚物（PNIPA）。利用活性酰胺与聚乙烯醇（PVA）中羟基的交换反应将PNIPA接枝在PVA链上得到接枝聚合物PVA-g-PNIPA。用化学交联法在W/O体系中将PVA-g-PNIPA制成微球。结果表明，接枝聚合物仍具有温敏性。接枝聚合物中PNIPA的含量随PNIPA/PVA（投料比）的增加而增加，并且影响微球的成球率。
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| 关 键 词： | 接枝共聚物 温敏性 活性酰胺 微球 PVA－g－PNIPA 合成 生物医用材料 聚乙烯醇 |
| 文章编号： | 0455-2059(2001)02-0095-05 |
| 修稿时间： | 2000年1月20日 |
Synthesis of Graft Copolymer PVA-g-PNIPA |
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| Wang Junqin,Chen Lan,Su Zhixing.Synthesis of Graft Copolymer PVA-g-PNIPA[J].Journal of Lanzhou University(Natural Science),2001,37(2):95-99. |
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| Authors: | Wang Junqin Chen Lan Su Zhixing |
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| Institution: | Wang Junqin1,Chen Lan2,Su Zhixing1 |
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| Abstract: | Linear homopolymer of N isopropylacrylamide has been made with AIBN as initiator and DMF as solvent, and it was thermosensitive.Graft copolymer PVA g PNIPA could be prepared through the reaction of the terminal active amide of PNIPA and the hydroxy group of PVA.Microspheres could be made of graft copolymer PVA g PNIPA with glutaraldehyde as cross link agent in water/oil system.It was found that graft copolymer PVA g PNIPA still had thermosensitivity,and the content of PNIPA in PVA g PNIPA could be controlled by the feed proportion of PNIPA and PVA, and microsphere was made readily but it could be affected by the content of PNIPA. |
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| Keywords: | graft copolymer thermosensitivity active amide microsphere |
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