| 维甲酸镍配合物的合成及其抑制白血病K562细胞增殖的研究 |
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| 引用本文： | 李勤喜,杨战军,李一志,马琳,刘青,王流芳.维甲酸镍配合物的合成及其抑制白血病K562细胞增殖的研究[J].兰州大学学报(自然科学版),2001,37(2):77-81. |
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| 作者姓名： | 李勤喜 杨战军 李一志 马琳 刘青 王流芳 |
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| 作者单位： | 1. 兰州大学化学化工学院,
2. 甘肃省建筑职工总医院, |
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| 基金项目： | 甘肃省自然科学基金(ZS991-A23-059-Y)及国家科委重点科技基金(96-901-05-126)资助项目. |
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| 摘 要： | 为了开发一种新型高效的维甲类抗癌新药，在无水、无氧、避光条件下合成了维甲酸镍的配合物,通过元素分析、摩尔电导、红外光谱、紫外光谱、差热及核磁共振氢谱测定了配合物的组成、结构和性质，其分子式为Ni(RA)
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| 关 键 词： | 维甲酸镍配合物 细胞增殖 诱导分化 白血病 维甲类抗癌药物 合成 K562细胞 |
| 文章编号： | 0455-2059(2001)02-0077-05 |
| 修稿时间： | 2000年1月18日 |
Studies on Synthesis and
Inhibitory Effect of Nickel Complex with Retinoic Acid on Proliferation of Leukemia K562
Cell |
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| Li Qinxi ,Zhu Qiaojun,Yang Zhanjun,Li Yizhi,Ma Lin,Liu Qing,Wang Liufang.Studies on Synthesis and
Inhibitory Effect of Nickel Complex with Retinoic Acid on Proliferation of Leukemia K562
Cell[J].Journal of Lanzhou University(Natural Science),2001,37(2):77-81. |
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| Authors: | Li Qinxi Zhu Qiaojun Yang Zhanjun Li Yizhi Ma Lin Liu Qing Wang Liufang |
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| Institution: | Li Qinxi 1,2,Zhu Qiaojun3,Yang Zhanjun1,Li Yizhi1,Ma Lin4,Liu Qing4,Wang Liufang 1,2 |
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| Abstract: | In order to develop a highly- effective antitumor drug of retinoic acid,a new complex of nickel with all-trans retinoic acid has been synthesized in absolute ethanol,without oxygen in darkness and characterized by elemental analysis,molar conductance,IR,UV,and HNMR spectrometry. Its formula is best described as Ni(RA)2 .3H2O. The inhibitory effects of ATRA and its nickel complexes on K562 cell lines have been investigated by using MTT colorimetric assay and clonic assay. The result showed that ATRA and its nickel complexes Ni(RA)2 .3H2O both have inhibitory effects on K562 cells. Especially,the complex Ni(RA)2 .3H2O has a far stronger inhibitory effect on K562 cells than the ligand ATRA (p＜0.001). |
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| Keywords: | retinoic acid complex cell line cell proliferation induce differentiation |
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