| 厚朴不同提取工艺对小鼠镇痛作用的影响 |
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| 引用本文： | 张慧敏,任虹,何瑶,刘芳.厚朴不同提取工艺对小鼠镇痛作用的影响[J].成都大学学报(自然科学版),2013,32(3):235-237. |
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| 作者姓名： | 张慧敏 任虹 何瑶 刘芳 |
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| 作者单位： | 成都中医药大学药学技术学院,四川成都,611137;成都中医药大学药学院中药材标准化教育部重点实验室中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都,611137 |
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| 摘 要： | 为探讨厚朴60%,70%,95%乙醇热回流提取工艺对小鼠镇痛作用的影响,采用小鼠甩尾实验和热板实验测定厚朴提取液的镇痛作用.实验结果显示,厚朴提取物组1,2,3号均能延长小鼠的甩尾痛域和热板痛域(P<0.05或P<0.01),其中60%乙醇热回流提取组有强于70%乙醇热回流提取组和95%乙醇热回流提取组的趋势,3种厚朴提取物对小鼠有明显的镇痛作用,60%乙醇热回流提取组较优.
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| 关 键 词： | 厚朴 提取工艺 甩尾实验 热板实验 |
Effects of Magnolia Officinalis with Different Extraction Techniques on Analgesia Function in Mice |
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| ZHANG Huimin
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REN Hong
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HE Yao
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LIU Fang.Effects of Magnolia Officinalis with Different Extraction Techniques on Analgesia Function in Mice[J].Journal of Chengdu University (Natural Science),2013,32(3):235-237. |
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| Authors: | ZHANG Huimin REN Hong HE Yao LIU Fang |
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| Institution: | 2 (1. Medical Teclnaology College, Chenb, du University of Traditional Chinese Medieince, Chengdu 611137, China; 2. Pharmacy College, The Ministry of Education Key Laboratory of Stmldardization of Chinese Herbal Medicine, State Key Latmratory Breeding ＂Base of Systematic Research, Development and Utilizalion of Chinese Mtxticine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China) |
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| Abstract: | This paper studies the effects of Magnolia Officinalis with 60% ,70% ,95% ethanol thermal cir- cumfluence extraction techniques on analgesic function in mice. Analgesia function of Magnolia Officinalis extract is studied by using mice tail-flick test and hot-plate test. The experimental results show that, Mag- nolia Oflicinalis group No. 1, No. 2 and No. 3 all can prolong the tail-flick and hot-plate pain threshold of mice （P 〈 0.05 or P 〈 0.01）, and the 60% ethanol thermal circumfluence extraction group is better than the 70% ethanol thermal circumfluence extraction group and 95 % ethanol thermal circumfluence extraction group. Magnolia Officinalis with three kinds of extracting techniques all have significant analgesic effects on mice, and the 60% ethanol thermal circumfluence extraction group is proved to be optimal. |
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| Keywords: | Magnolia Officinalis extraction technique tail-flick test hot-plate test |
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