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| 复方天麻制剂外周镇痛机理研究 | |
| 引用本文： | 胡一冰,张元,潘惠娟,许建阳,邱德文.复方天麻制剂外周镇痛机理研究[J].成都大学学报(自然科学版),2009,28(4):302-304. |
| 作者姓名： | 胡一冰 张元 潘惠娟 许建阳 邱德文 |
| 作者单位： | 1. 成都大学,生物产业学院,四川,成都,610106 2. 北京联合大学,生物化学工程学院,北京,100023 3. 武警总医院,北京,100039 4. 贵阳中医学院,贵州,贵阳,550002 |
| 摘 要： | 探讨复方天麻制剂外周镇痛机理,即对神经递质和c-fos基因表达的影响.以福氏完全佐剂制作慢性疼痛模型,高效液相色谱法测定血清中5-HTP、5-HI AA含量,免疫组织化学法检查外周组织c-fos的表达.实验结果表明,复方天麻制剂降低血清5-HTP、5-HI AA含量,抑制外周组织c-fos表达;通过降低血清吲哚类神经递质含量,抑制疼痛基因表达达到外周镇痛作用. |
| 关 键 词： | 复方天麻制剂 疼痛模型 神经递质 c-fos基因 |
Effect of Mechanism Study of Peripheral Analgesic by Compound Gastrodia Tuber Preparation |
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| HU Yibing,ZHANG Yuan,PAN Huijuan,XU Jianyang,QIU Dewen.Effect of Mechanism Study of Peripheral Analgesic by Compound Gastrodia Tuber Preparation[J].Journal of Chengdu University (Natural Science),2009,28(4):302-304. | |
| Authors: | HU Yibing ZHANG Yuan PAN Huijuan XU Jianyang QIU Dewen |
| Institution: | HU Yibing1,ZHANG Yuan2,PAN Huijuan3,XU Jianyang3,QIU Dewen4(1.School of Bioindustry,Chengdu University,Chengdu 610106,China,2.College of Biochemical Engineering,Beijing Union University,Beijing 100023,3.General Hospital of People's Armed Police Forces,Beijing 100039,4.Guiyang College of Traditional Chinese Medicine,Guiyang 550002,China) |
| Abstract: | To discuss the effect of mechanism study of peripheral analgesic produced by compound Gastrodia Tuber preparation on expression of neurotransmitters and c-fos gene,based on FCA induced pain model,contents of 5-HTP and 5-HIAA in serum were measured by high-performance liquid chromatography and the expression of c-fos gene in peripheral tissue by immunohistochemical method.The findings show that compound Gastrodia Tuber preparation decreases the content of 5-HTP and 5-HIAA in serum and restrains the c-fos exp... |
| Keywords: | Gastrodia Tuber pain model neurotransmitters c-fos gene |
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