| HPLC法同时测定阿司匹林片中阿司匹林与杂质水杨酸含量 |
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| 引用本文： | 姚倩,郭晓强,邬晓勇,颜军,刘嵬,曾桂芬,苟小军.HPLC法同时测定阿司匹林片中阿司匹林与杂质水杨酸含量[J].成都大学学报(自然科学版),2008,27(1):5-8. |
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| 作者姓名： | 姚倩 郭晓强 邬晓勇 颜军 刘嵬 曾桂芬 苟小军 |
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| 作者单位： | 成都大学,四川省药用微生物资源重点实验室,四川,成都,610106 |
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| 摘 要： | 建立一HPLC法用于测定阿司匹林片中阿司匹林和杂质水杨酸的含量.以C18柱为固定相,以乙腈-甲醇-0.01 mol/L磷酸二氢钾溶液-三乙胺溶液(5∶48∶47∶0.1,用磷酸调pH值至3.3~3.4)为流动相,流速1.0mL/min,检测波长280 nm,在这一色谱条件下,阿司匹林和水杨酸分离良好;阿司匹林在0.183~0.427 mg/mL内,线性关系良好,r=0.9997,平均回收率为99.81%,RSD为0.24%(n=6);水杨酸在1~12μg/mL内,线性关系良好,r=0.9999,平均回收率为101.09%,RSD为0.77%(n=6).本法简单、灵敏、准确、精密,可作为阿司匹林片的质量控制方法.
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| 关 键 词： | HPLC 阿司匹林片 阿司匹林 水杨酸 测定 |
| 文章编号： | 1004-5422(2008)01-0005-04 |
| 修稿时间： | 2008年1月15日 |
Simultaneous Determination of Aspirin and Salicylic Acid Impurity in Aspirin Tablets by HPLC |
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| YAO Qian,GUO Xiaoqiang,WU Xiaoyong,YAN Jun,LIU Wei,ZENG Guifen,GOU Xiaojun.Simultaneous Determination of Aspirin and Salicylic Acid Impurity in Aspirin Tablets by HPLC[J].Journal of Chengdu University (Natural Science),2008,27(1):5-8. |
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| Authors: | YAO Qian GUO Xiaoqiang WU Xiaoyong YAN Jun LIU Wei ZENG Guifen GOU Xiaojun |
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| Abstract: | To establish a HPLC method for the determination of aspirin and salicylic acid in aspirin tablets,acetonitrile-methanol-formic acid(40∶59∶1) was used as extracted solvent.The mobile phase was composed of acetonitrile-methanol-0.01 mol/L potassium dihydrogen phosphate(adjusting pH to 3.3～3.4 with phosphoric acid).A linearity with a good correlation coefficient was yielded from 0.183 to 0.427 mg/mL for aspirin(r=0.9997).The average recovery was 99.81% and RSD was 0.24%.A linearity with a good correlation coefficient was yielded from 1 to 12 μg/mL for salicylic acid(r=0.9999).The average recovery was 101.09% and RSD was 0.77%.This method is simple,sensitive,accurate and precise,and can be used for the quality control of the preparation. |
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| Keywords: | HPLC aspirin tablets aspirin salicylic acid determination |
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