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Synthesis of O-Phosphorylated Oligopeptides Using Phosphoramidite
作者姓名:李艳梅  赵玉芬
作者单位:LI Yanmei ZHAO Yufen Waldmann Herbert Bioorganic Phosphorus Chemistry Laboratory,Department of Chemistry,Tsinghua University,Beijing 100084,China; Institute of Organic Chemistry,University of Karlsruhe,76128 Karlsruhe,Germany
基金项目:the National Natural Science Foundationof China! ( No.2 980 2 0 0 6),Chao Guangbiao High-Tech Fund!( No.97JC0 5 9
摘    要:


Synthesis of O-Phosphorylated Oligopeptides Using Phosphoramidite
LI Yanmei,ZHAO Yufen,Waldmann Herbert.Synthesis of O-Phosphorylated Oligopeptides Using Phosphoramidite[J].Tsinghua Science and Technology,2000,5(2):163-166.
Authors:LI Yanmei  ZHAO Yufen  Waldmann Herbert
Abstract:Reversible protein phosphorylation is of great importance in the regulation of many cellular processes. Structurally well defined compounds are needed for the study of the roles of the phospho proteins in biological processes. In this paper, O phosphorylated oligopeptides were synthesized using bis alkyloxy N,N dialkylphosphoramidite reacting with the oligopeptide followed by oxidation. Many hydroxyl groups in oligopeptides can be phosphorylated in one step.
Keywords:phosphorylated oligopeptide  phosphoramidite  oxidation  synthesis
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