| Neuron Protective Constituents from Rheum Nanum and Rheum Sublanceolatum |
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| 作者姓名： | 向兰 雷帆 刑东明 王伟 郑俊华 |
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| 作者单位： | [1]Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China [2]School of Pharmacy, Shandong University, Ji＇nan 250012, China [3]School of Pharmaceutical Science, Peking University, Beijing 100083, China |
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| 基金项目： | Supported by the National Natural Science Foundation of China（No. 39470849） |
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| 摘 要： | The neuron protective activity of the chemical constituents from Rheum nanum and Rheum sublanceolatum in vitro was investigated using cultured embryonic mouse cortical cells exposed to oxygen-glucose deprivation. The protective effect was quantitatively evaluated by measuring the lactate dehydrogenase release rate. Most of the compounds reduce the lactate dehydrogenase release rate, including emodin, chrysophanol-8-O-β-D-glucopyranoside, 6-hydroxymusizin-8-O-β-D-glucopyranoside, gnetin C, torachrysone-8-O-β-D-glucopyranoside, and maesopsin, and all possess potent neuron protective activity. Chrysophanol and aloe-emodin exhibit neuron protection only at low concentrations. Emodin-8-O-β-D-glucopyranoside protects the neuron cells at high concentration. Aloe-emodin-8-O-β-D- glucopyranoside is inactive.
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| 关 键 词： | 感冒 病毒侵袭 神经细胞保护 皮层细胞 |
| 收稿时间： | 2004-12-17 |
| 修稿时间： | 2004-12-172005-01-14 |
Neuron Protective Constituents from Rheum Nanum and Rheum Sublanceolatum |
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| Lan Xiang, &#x; &#x;, Fan Lei, , Dongming Xing,
ì, Wei Wang, ÿ,Junhua Zheng,
࿊.Neuron Protective Constituents from Rheum Nanum and Rheum Sublanceolatum[J].Tsinghua Science and Technology,2005,10(4):426-429. |
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| Authors: | Lan Xiang &#x; &#x; Fan Lei Dongming Xing
ì Wei Wang ÿ Junhua Zheng
࿊ |
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| Institution: | aDepartment of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China;bSchool of Pharmacy, Shandong University, Ji'nan 250012, China;cSchool of Pharmaceutical Science, Peking University, Beijing 100083, China |
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| Abstract: | The neuron protective activity of the chemical constituents from Rheum nanum and Rheum sublanceolatum in vitro was investigated using cultured embryonic mouse cortical cells exposed to oxygen-glucose deprivation. The protective effect was quantitatively evaluated by measuring the lactate dehydrogenase release rate. Most of the compounds reduce the lactate dehydrogenase release rate, including emodin, chrysophanol-8-O-β-D-glucopyranoside, 6-hydroxymusizin-8-O-β-D-glucopyranoside, gnetin C, torachrysone-8-O-β-D-glucopyranoside, and maesopsin, and all possess potent neuron protective activity. Chrysophanol and aloe-emodin exhibit neuron protection only at low concentrations. Emodin-8-O-β-D-glucopyranoside protects the neuron cells at high concentration. Aloe-emodin-8-O-β-D- glucopyranoside is inactive. |
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| Keywords: | Rheum nanum R sublanceolatum chemical constituents neuron protective activity |
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