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Characterization of the Antigenicity and Immunogenicity of the Escherichia Coli Produced RNase Domain of the Classical Swine Fever Virus Glycoprotein E~(rns) |
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| Authors: | QI Yun LIU Lianchi WANG Ji CHEN Yinghua Laboratory of Immunology |
| Institution: | QI Yun 1,2,LIU Lianchi 1,WANG Ji 1,CHEN Yinghua 1,** 1. Laboratory of Immunology,Department of Biological Sciences , Biotechnology,Tsinghua University,Beijing 100084,China,2. Protein Science Laboratory of MOE |
| Abstract: | Erns is a highly glycosylated envelope protein of classical swine fever virus (CSFV) with RNase activity. Erns can induce neutralizing antibodies and provide immune protection against CSFV infection. In this study, the RNase domain of the Erns was produced in Escherichia coli. Its reactivity with CSFV-positive sera and its ability to induce antibodies and to provide protective immunity were then investigated. The serological tests showed that the prokaryotically expressed RNase domain of the Erns retained i... |
| Keywords: | classical swine fever virus (CSFV) envelope glycoprotein Erns neutralizing antibodies protective immunity |
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