手性分子与NMR谱

目的 研究手性分子与核磁共振(NMR)谱图之间的关系,为手性化合物研究提供参考.方法 通过举例分析,阐述手性分子与NMR谱图之间的关系.如毗邻一个手性中心的亚甲基中的2个质子化学位移并非等价,-CH2-基团实际上是-CHaHb-结构.此方法可以用来确定ee%(对映体过量)值.结果 给出了应用手性衍生试剂、手性溶剂化试剂和手性位移试剂来确定ee%值的方法;此外,对手性螺环化合物的1H NMR谱图也进行了讨论.结论 对于手性分子与NMR谱图之间关系的研究,可为通过NMR谱图表征手性分子提供参考.

Chiral molecules and NMR spectra

Purposes-To address the relationship between the chiral molecules and NMR spectra and to provide reference for the research into chiral compounds.Methods-Examples are analyzed to describe the relations between chiral molecules and NMR spectra.Two protons in the methylene adjacent to a chiral center are not chemical shift equivalence, group-CH2-actually is-CHaHb-structure.The methods can be used to determine the value of ee% (enantiomeric excess).Results-The methods for determining the value of ee% are given by applying chiral derivative agents, chiral solvating agents and chiral shift reagents.Besides, the 1H NMR spectra of chiral spiro-compounds are discussed.Conclusion-The analysis and discussion herein is a very good reference for the chiral molecules characterized by NMR spectra.