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求解MSA问题的新型遗传算法
引用本文:胡桂武,牛熠,杨胜良,黄辉.求解MSA问题的新型遗传算法[J].兰州理工大学学报,2005,31(3):91-93.
作者姓名:胡桂武  牛熠  杨胜良  黄辉
作者单位:1. 广东商学院,数学与计算科学系,广东,广州,510320
2. 东莞理工学院,广东,东莞,523106
3. 兰州理工大学,甘肃,兰州,730050
基金项目:国家自然科学基金(30230350)
摘    要:为了克服传统遗传算法求解MSA问题速度慢的缺点,提出了一种新型自适应遗传算法,不使用交叉算子,只使用变异和选择算子,提出了在算法初始化时引入种子的策略,用星比对算法生成一个种子,保证了解的质量,使用灾变算子来确保算法的搜索能力,该算法模拟了自然界进化的周期性,较好地解决了群体多样性和收敛深度的矛盾。

关 键 词:MSA  遗传算法  生物信息学  星比对  算子
文章编号:1000-5889(2005)03-0091-03
修稿时间:2004年4月30日

New genetic algorithm of MSA solution problem
HU Gui-Wu,Niu Yi,YANG Sheng-liang,HUANG Hui.New genetic algorithm of MSA solution problem[J].Journal of Lanzhou University of Technology,2005,31(3):91-93.
Authors:HU Gui-Wu  Niu Yi  YANG Sheng-liang  HUANG Hui
Abstract:Multiple sequence alignment (MSA) is a typical NP problem,in order to solve this time-comsuming problem which genetic algorithm will encounter in multiple sequence alignment,a new adaptive genetic algorithm was presented.The algorithm employed only mutation operator and selection operator to produce the offspring,instead of crossover operator.Further,seed strategy used in the procedure of initialization ensured the quality of result,and the seed was produced by star alignment algorithm.In addition,a specific cataclysm operator was designed to ensure its searching capability.The algorithm simulates the recurrence of nature evolution process was simulated with this algorithm,and the contradiction among the diversity of population and the convergence speed were solved.
Keywords:multiple sequence alignment  genetic algorithms  bio-informatics  star alignment  operator
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