| 甲醛吸入对小鼠脾淋巴细胞分泌白细胞介素-2水平的影响 |
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| 引用本文： | 刘爱平,张晓林,杨安平. 甲醛吸入对小鼠脾淋巴细胞分泌白细胞介素-2水平的影响[J]. 佛山科学技术学院学报(自然科学版), 2008, 26(3) |
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| 作者姓名： | 刘爱平 张晓林 杨安平 |
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| 作者单位： | 佛山科学技术学院,检药系,广东,佛山,528000;佛山科学技术学院,检药系,广东,佛山,528000;佛山科学技术学院,检药系,广东,佛山,528000 |
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| 摘 要： | 目的研究甲醛吸入对小鼠脾淋巴细胞分泌白细胞介素（IL）-2水平的影响。方法选用健康清洁级昆明种小鼠48只．随机分成4组（即阴性对照组．21．42．84mg／m3染毒组）．每组12只．用静式吸入染毒方式染毒12W处死后．测定小鼠脾淋巴细胞分泌IL-2的水平。结果甲醛吸入染毒组小鼠脾淋巴细胞分泌IL-2水平均随染毒剂量的升高而呈明显下降趋势（P〈0．05或，P〈0．01）。结论吸入甲醛可导致小鼠脾淋巴细胞分泌IL-2水平的下降。
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| 关 键 词： | 甲醛 脾淋巴细胞 白细胞介索-2 |
Effect of formaldehyde inhalation on the produc-tion of IL-2 from mouse spleen lymphocyte |
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| LIU Ai-ping,ZHANG Xiao-lin,YANG An-ping. Effect of formaldehyde inhalation on the produc-tion of IL-2 from mouse spleen lymphocyte[J]. Journal of Foshan University(Natural Science Edition), 2008, 26(3) |
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| Authors: | LIU Ai-ping ZHANG Xiao-lin YANG An-ping |
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| Abstract: | Objective To study the effect of formaldehyde(FA) inhalation on the Interleukin-2(IL-2) production from mouse spleen lymphocyte.Methods Fourty-eight KM mice were randomly divided into 4 groups as following:negative control group,21,42,84 mg/m3 FA inhalation group.Mice were exposed to different dose of FA by inspiration in a static total enclosure chamber for 12 weeks.The level of IL-2 production from mouse spleen lymphocyte were measured.Results the level of IL-2 production from mouse spleen lymphocyte showed a significant decline tendency with dose increased in FA inhalation group compared with negative control group(P<0.05 or P<0.01).Conclusion formaldehyde inhalation can decrease the level of IL-2 production from spleen lymphocytes. |
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| Keywords: | formaldehyde(FA) spleen lymphocyte interleukin-2(IL-2) |
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