| 钙库调控钙内流信号机制的研究进展 |
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| 引用本文： | 王丽娟,赵红,陈文媛,耿越.钙库调控钙内流信号机制的研究进展[J].科技信息,2009(27):40-41. |
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| 作者姓名： | 王丽娟 赵红 陈文媛 耿越 |
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| 作者单位： | 山东师范大学生命科学学院; |
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| 摘 要： | 钙库调控的钙内流（SOCE）A--种普遍的信号过程。随着RNA干扰技术的发展，SOCE过程中两个重要分子被确定：STIM1和Orai1。STIM1是内质网Ca。“‘感受器”，钙库排空后，可能会在内质网进行重新分配，并移向质膜，但似乎并不插入质膜。STIM1将信号传递给质膜Orai1蛋白．Orai1是SOCC孔隙形成的亚基。
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| 关 键 词： | 钙库操纵的钙通道(SOCE) STIM1 Orai1 |
The Research Progress About the Signal Mechanism of SOCE and the Composed Molecules of SOCC |
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| WANG Li-juan ZHAO Hong CHEN Wen-yuan GENG Yue.The Research Progress About the Signal Mechanism of SOCE and the Composed Molecules of SOCC[J].Science,2009(27):40-41. |
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| Authors: | WANG Li-juan ZHAO Hong CHEN Wen-yuan GENG Yue |
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| Institution: | Science of College;Shandong Normal University;Jinan Shandong;250014 |
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| Abstract: | Store-operated Ca2+ entry (SOCE) is a ubiquitous signal pathway. With the improvement of RNA interferes technique, two majorplayers in the mechanisms of store-operated Ca2+channels have been discovered: STIM1 and Orai1. STIM1 is an Ca2+ sensor in endoplasmic reticulum.After the Ca2+ store depleted, it appears to act by redistributing within the endoplasmic reticulum, approaching the plasma membrane. It does notseemed to insert into the plasma membrane. STIM1 transfer signals to plasma membrane Orai1, which ... |
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| Keywords: | SOCE STIM1 Orai1 |
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