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| 眼镜蛇毒神经生长因子对成年猫坐骨神经损伤治疗效果的实验室观察 | |
| 引用本文： | 陈丽华,李小兵,雄郁良.眼镜蛇毒神经生长因子对成年猫坐骨神经损伤治疗效果的实验室观察[J].大理学院学报,2003,2(3):1-4. |
| 作者姓名： | 陈丽华 李小兵 雄郁良 |
| 作者单位： | 1. 大理学院基础医学部组织学与胚胎学教研室,云南大理,671000 2. 大理学院基础医学部病理解剖学教研室,云南大理,671000 3. 中科院昆明动物研究所毒素研究室,云南昆明,650223 |
| 基金项目： | 云南省自然科学基金资助项目(2001C0020Q) |
| 摘 要： | 目的 :探讨从眼镜蛇毒分离纯化出的神经生长因子(nervegrowthfactor,NGF)对成年猫坐骨经损伤后的影响。方法 :本实验制成成年猫坐骨神经损伤模型 ,损伤局部注射蛇毒NGF(2μg/kg/d) ,分别治疗10d和30d ,并与对照组(损伤坐骨神经 ,不给药物)比较。结果 :眼镜蛇毒NGF在神经损伤早期应用能减轻神经纤维发生的溃变 ,促进神经纤维再生。结论 :损伤局部长时间注射NGF会导致神经纤维增生过度 ,丧失传导功能 |
| 关 键 词： | 蛇毒神经生长因子 坐骨神经损伤再生 |
| 文章编号： | 1672-2345(2003)03-0001-04 |
| 修稿时间： | 2003年4月29日 |
Effects of a NGF Isolated and Purified From the Venom of Naja naja atra on Injured Sciatic Nerve in the Adult Cat |
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| CHAN Li-hua,LI Xiao-bing,XIONH Yu-liang.Effects of a NGF Isolated and Purified From the Venom of Naja naja atra on Injured Sciatic Nerve in the Adult Cat[J].Journal of Dali University,2003,2(3):1-4. | |
| Authors: | CHAN Li-hua LI Xiao-bing XIONH Yu-liang |
| Abstract: | Objective:investigate the therapeutic effects of a NGF isolated and purified from the venom of Naja naja atra on injured sciatic nerves in adult cat.Methods:for model of sciatic nerves crush lesion in cats were made.One group were peritoneallyinjected NGF(2ug/kg)everyday for 10days and 30days respectively;another group were not injected NGF everyday for 10days and 30days respectively.Results:The results showed that NGF can significantly reduce degeneration of the nerve fibers,promote regeneration as compared with the control(p<0.01)after lesion early.Conclusions:The continues injected NGF everyday can significantly stimulate regeneration of nerve fibers,theconductive function of injured peripheral nerve was disappear. |
| Keywords: | NGF from the venom of Naja naja atra Sciatic nerve lesion Regeneration |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |