| DRD3基因多态性与精神分裂症的相关性研究 |
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| 引用本文： | 阿周存,李合,马志敏,张励.DRD3基因多态性与精神分裂症的相关性研究[J].大理学院学报,2004,3(1):3-4,23. |
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| 作者姓名： | 阿周存 李合 马志敏 张励 |
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| 作者单位： | 大理学院检验系生化分子生物学教研室,云南大理,671000 |
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| 基金项目： | 云南省教育厅资助项目 (0011091) |
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| 摘 要： | 目的 :研究多巴胺D3受体 (DRD3)基因的多态性与精神分裂症的关系。方法 :应用PCR -RFLP技术 ,在90名无亲缘关系的正常汉族人和80名精神分裂症患者中对DRD3基因第一外显子内Ser9Gly多态性进行分析。结果 :正常汉族人群中 ,DRD3等位基因1(Ser)和2(Gly)的频率分别为0.71和0.29。在正常对照组和精神分裂症组之间 ,等位基因频率 (X2=0.02,υ=1,P>0.05)和各种基因型 (P值均大于0.05)分布无显著性差异。结论 :DRD3基因的Ser9Gly多态性与中国汉族人群精神分裂症不相关。
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| 关 键 词： | 多巴胺D3受体基因 多态性 精神分裂症 |
| 文章编号： | 1672-2345(2004)01-0003-03 |
An Association Study of Polymorphism of DRD3 Gene with Schizophrenia in Chinese Han Population |
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| AZhou-cun,LI He,MAZhi-min,ZHANG Li.An Association Study of Polymorphism of DRD3 Gene with Schizophrenia in Chinese Han Population[J].Journal of Dali University,2004,3(1):3-4,23. |
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| Authors: | AZhou-cun LI He MAZhi-min ZHANG Li |
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| Abstract: | Objective:To study the association of the dopamine D3receptor (DRD3)gene with schizophrenia.Methods:The Ser9gly polymorphism in exon1of DRD3gene was investigated by polymerase chain reaction and restriction fragment length polymorphism analysis(PCR-RFLP)in90normal Chinese Han and80patients with schizophrenia.Results:The frequency of allele1and allele2of the Ser9gly polymorphism in exon1of DRD3gene is0.71and0.29in Chinese Han population,respectively.No significant differences in genotypes and allelic frequencies were observed between schizophrenia and control group.Conclusions:The Ser9gly polymorphism of DRD3gene is not associated with schizophrenia in Chinese Han population. |
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| Keywords: | The dopamine D3receptor gene(DRD3) Polymorphism Schizophrenia |
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