| RAD51基因135G/C单核苷酸多态性与男性不育的相关性研究 |
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| 引用本文： | 阿周存,李娜.RAD51基因135G/C单核苷酸多态性与男性不育的相关性研究[J].大理学院学报,2006,5(10):34-35,39. |
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| 作者姓名： | 阿周存 李娜 |
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| 作者单位： | 1. 大理学院生命科学与化学学院遗传学教研室,云南,大理,671000
2. 四川大学华西医院医学遗传室,四川成都,610073 |
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| 摘 要： | 目的：研究RAD51基因135G／C单核苷酸多态性与男性不育的关系。方法：用PCR—RFLP技术，在255个正常生育男性和271例男性不育患者中，对RAD51基因135G／C单核苷酸多态位点的频率分布进行了分析。结果：在正常男性和男性不育患者组之间，RAD51基因135G／C的等位基因频率和基因型频率均无显著性差异（P值丝均大于0．05）。结论：RAD51基因135G／C单核苷酸多态性与男性不育的易感性不相关。
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| 关 键 词： | RAD51基因 多态性 男性不育 |
| 文章编号： | 1672-2345（2006）10-0034-02 |
| 收稿时间： | 03 6 2006 12:00AM |
| 修稿时间： | 2006-03-06 |
Study on Association between the Polymorphism of Single Nucleotide Polymorphism 135G/C in RAD51 Gene and Male Infertility |
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| A Zhou-cun,Li Na.Study on Association between the Polymorphism of Single Nucleotide Polymorphism 135G/C in RAD51 Gene and Male Infertility[J].Journal of Dali University,2006,5(10):34-35,39. |
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| Authors: | A Zhou-cun Li Na |
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| Institution: | 1. Department of Genetics, Biology and Chemistry Faculty, Dali University, Dali, Yunnan 671000, China; 2.Department of Medical Genetics, West China Hospital, Sichuan University |
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| Abstract: | Objective: To study the relationship between the polymorphism of single nucleotide polymorphism(SNP) 135G/C in RAD51 gene and male infertility.Methods: Using multiplex polymerase chain reaction(multi-PCR) and polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) analysis,the allele and genotype frequencies of SNP 135G/C in RAD51 gene were investigated in 271infertile patients and 255 fertile men as controls.Results: No significant differences in allele and genotype frequencies of SNP 135G/C between infertile patients and controls were observed(P>0.05).Conclusion: The polymorphism of SNP 135G/C in RAD51 gene is not associated with the susceptibility to male infertility. |
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| Keywords: | RAD51 gene polymorphism male infertility |
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