| 7-苄基-5-6-7-8-四氢咪唑并[1,5-a]哌嗪的合成 |
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| 引用本文： | 代玉松.7-苄基-5-6-7-8-四氢咪唑并[1,5-a]哌嗪的合成[J].科学技术与工程,2012,12(2):444-446. |
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| 作者姓名： | 代玉松 |
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| 作者单位： | 青岛科技大学化工学院,青岛,266042 |
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| 摘 要： | 以4-咪唑甲醛和2-苄胺基乙醇为原料,经还原氨化、氯代及环合反应合成了7-苄基-5,6,7,8-四氢咪唑并1,5-a]哌嗪.研究了反应溶剂和碱对环合反应的影响,得到较好的工艺条件,总收率达到53％.
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| 关 键 词： | 7-苄基-5 6 7 8-四氢咪唑并[1 5-a]哌嗪 4-咪唑甲醛 还原氨化 |
| 收稿时间： | 2011/10/27 0:00:00 |
| 修稿时间： | 2011/11/8 0:00:00 |
Synthesis of 7-Benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine |
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| daiyusong.Synthesis of 7-Benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine[J].Science Technology and Engineering,2012,12(2):444-446. |
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| Authors: | daiyusong |
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| Institution: | (College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042,P.R.China) |
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| Abstract: | 7-benyzl-5,6,7,8-tetrahydroimidazo1,5-a]pyrazine was synthesized from 4-imidazole carboxyaldehyde and 2-benzyl aminoethanol in a sequence of reductive amination, chlorization and cyclization in an overall yield of 53%. The effects of solvent and base on cyclization reaction were examined and the optimum reaction conditions were obtained. |
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| Keywords: | 7-benyzl-5 6 7 8-tetrahydroimidazo[1 5-a]pyrazine 4-imidazole carboxyaldehyde reductive amination |
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