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黄芩提取物及含药血清体外抑制呼吸道合胞病毒作用的实验研究
引用本文:杨洁,刘萍.黄芩提取物及含药血清体外抑制呼吸道合胞病毒作用的实验研究[J].科学技术与工程,2007,7(12):2784-2786.
作者姓名:杨洁  刘萍
作者单位:解放军总医院药品保障中心,北京,100853
摘    要:研究了黄芩提取物及其含药血清体外抑制呼吸道合胞病毒(RSV)的作用。通过细胞培养,采用观察细胞病变(CPE)和活细胞染色计数法(MTT),观察清热抗感冲剂及其含药血清在Hep-2细胞中抑制RSV的作用。结果表明:黄芩提取物及其含药血清具有不同程度抑制RSV病毒复制作用,其半数中毒浓度(TC50)分别为3924mg/L、1/4.35稀释度;半数有效浓度(IC50)为165mg/L、1/54稀释度;治疗指数分别为23.78、10.83。这表明黄芩提取物及其含药血清具有抑制RSV在Hep-2细胞内复制的作用。

关 键 词:RSV  黄芩提取物  含药血清  抗病毒  大鼠
文章编号:1671-1819(2007)12-2784-03
修稿时间:2007-02-05

Experimental Research on the Scutellaria baicalensis Antivirus Function in vitro Georgi Extractant
YANG Jie,LIU Ping.Experimental Research on the Scutellaria baicalensis Antivirus Function in vitro Georgi Extractant[J].Science Technology and Engineering,2007,7(12):2784-2786.
Authors:YANG Jie  LIU Ping
Institution:Department of Pharmacy, Chinese PLA General Hospital, Beijing 100853, P. R. China
Abstract:To explore the antivirus function in vitro of Scutellaria baicalensis Georgi extractant by researching its effect on inhibiting RSV, the Hep-2 cells were cultured. Extractant effect on inhibiting RSV was studied by observing CPE and counting cells with MTT assay. The results show that Scutellaria baicalensis Georgi extractant and the serum with this drug can inhibit the replication of RSV in different degree. The TC50 and the dilution rate are 3 924 mg/L and 1/4. 35. The IC50 and the dilution rate are 165 mg/L and 1/54. The TI and the dilution rate are 23.78 and 10.83 respectively. Scutellaria baicalensis Georgi extractant and the serum with this drug can inhibit the replication of RSV in the Hep-2 cells.
Keywords:RSV  Scutellaria baicalensis Georgi extractant  serum with Scutellaria baicalensis Georgi extractant  antivirus  rat
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