| HLA-G蛋白在不同孕期胎盘绒毛中的表达及意义 |
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| 引用本文： | 朱晓明.HLA-G蛋白在不同孕期胎盘绒毛中的表达及意义[J].科学技术与工程,2010,10(3). |
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| 作者姓名： | 朱晓明 |
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| 作者单位： | 第四军医大学唐都医院妇产科,西安,710038 |
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| 摘 要： | 人类白细胞抗原-G(HLA-G)主要表达于胎盘组织中,在维持母胎界面的免疫耐受过程中发挥着关键作用。为研究HLA-G在正常胎盘形成过程中的表达模式,实验检测了妊娠不同阶段的胎盘绒毛组织中HLA-G蛋白的表达水平。实验结果显示HLA-G蛋白在孕6周与7周的绒毛中表达量最高,从孕8周开始,表达量逐渐下降,至足月时,表达量达到最低水平。由此推测HLA-G在妊娠早、中期与胎盘形成有关,在妊娠晚期可能参与妊娠维持。
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| 关 键 词： | 人类白细胞抗原-G 绒毛 妊娠 |
| 收稿时间： | 2009/10/14 0:00:00 |
| 修稿时间： | 2009/10/14 0:00:00 |
Expression of HLA-G in chorionic villi at different stages of gestation |
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| Zhu Xiao Ming.Expression of HLA-G in chorionic villi at different stages of gestation[J].Science Technology and Engineering,2010,10(3). |
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| Authors: | Zhu Xiao Ming |
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| Institution: | Department of Obstetrics and Gynecology/a>;Tangdu Hospital/a>;The Fourth Military Medical University/a>;Xi'an/a>;710038/a>;P.R.China |
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| Abstract: | Human leukocyte antigen-G(HLA-G) is expressed in placenta,in which it thought to play a key role in maintaining the maternal-fetal immune tolerance.The expression of HLA-G in human chorionic villi is examined at different stages of gestation to investigate the expression pattern of HLA-G during normal placentation.The results showed that HLA-G protein expression reached a peak level at gestational weeks 6 and 7,then gradually decreased from week 8 to third trimester in normal chorionic villi.These results l... |
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| Keywords: | HLA-G chorionic villi pregnancy |
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