肥胖低通气综合征患者血清瘦素水平的变化及意义

为了研究血清瘦素在肥胖低通气综合征(OHS)患者体内的变化及其意义,通过酶联免疫吸附测定(ELISA)法测定了所有受试者的血清瘦素水平,选取OHS组23例、肥胖OSA组40例、非肥胖OSA组14例、单纯肥胖组6例和正常对照组10例。比较所有受试者的一般资料、血清瘦素水平和多导睡眠参数,分析肥胖各组的血气分析结果。对瘦素与其他参数进行相关性分析,并分析其对OHS的诊断预测。结果表明OHS组BMI、颈围明显高于其他组。OHS组血清瘦素水平高于其他各组,且各组之间均存在明显差异(P 0.05)。血清瘦素水平与BMI、颈围、腰围、臀围、Pa CO_2、动脉血HCO_3~-呈正相关,与Pa O_2呈负相关。BMI、颈围、腰围和血清瘦素水平对OHS具有诊断预测作用。可见OHS组血清瘦素水平较肥胖OSA组、单纯肥胖组明显升高,除了肥胖因素外,OHS本身也可成为血清瘦素水平升高的原因,血清瘦素水平的升高可以作为OHS的诊断预测指标之一。

Changes and Significance of Serum Leptin Levels in Patients with Obesity Hypoventilation Syndrome

In order to study the change and significance of serum leptin in obese hypoventilation syndrome (OHS) patients. Serum leptin levels in patients with OHS were studied by enzyme-linked immunosorbent assay (ELISA) and polysomnography.Choose 23 patients in the OHS group, 40 patients with obesity OSA without OHS (obese OSA group), 14 patients without obesity OSA (non-obese OSA group), and simple obesity were selected. 6 cases (simple obesity group) and healthy adults 10 cases (normal control group). The gender, age, neck circumference, waist circumference, BMI and other general data, serum leptin levels and polysomnography parameters were compared among all subjects. Blood gas analysis was performed in OHS group, obese OSA group and simple obesity group, and the results were compared. Correlation analysis of leptin and other related parameters, and analysis of the diagnostic prediction of OHS by indicators such as leptin. The results show that the BMI of the OHS group (42.6±8.7) kg/m2, P<0.05] and the neck circumference (45.5±4.7) cm, P<0.05] were significantly higher than the other groups. Younger than other groups (30 ± 11) years old, P < 0.05]. The serum leptin level in the OHS group (14.4±1.1) ng/mL] was significantly higher than that in the obese OSA group (11.9±0.8) ng/mL, P<0.05], and the simple obesity group (9.3±0.9) ng /mL, P<0.05)], non-obese OSA group (10.8±0.9) ng/mL, P<0.05] and normal control group 7.0±0.7) ng/mL, P<0.05) There was a significant difference between the groups (P < 0.05). Serum leptin levels and BMI (r=0.38, P<0.01), neck circumference (r=0.35, P<0.01), waist circumference (r=0.37, P<0.01), hip circumference (r= 0.38, P<0.01), PaCO2 (r=0.59, P<0.01), arterial blood HCO3- (r=0.48, P<0.01) and venous blood HCO3- (r=0.29,P <0.01) was positively correlated and negatively correlated with PaO2 (r=-0.45, P<0.01). BMI, neck circumference, waist circumference and serum leptin levels have diagnostic predictive effects on OHS. It is concluded that serum leptin levels in OHS patients are significantly higher than those in obese OSA group and simple obesity group. In addition to obesity, OHS itself can also be a cause of elevated serum leptin levels,Increased serum leptin levels can be used as one of the diagnostic predictors of OHS.