| 正交实验法优选复方烧伤膏的醇提工艺 |
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| 引用本文： | 张雅,缪珊,曹蔚,官浩,胡晓龙,李小强,张月,胡大海,王四旺.正交实验法优选复方烧伤膏的醇提工艺[J].科学技术与工程,2012,12(6):1238-1240. |
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| 作者姓名： | 张雅 缪珊 曹蔚 官浩 胡晓龙 李小强 张月 胡大海 王四旺 |
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| 作者单位： | 1. 第四军医大学药学院天然药物学教研室,西安,710032
2. 第四军医大学西京医院烧伤与皮肤外科,西安,710032 |
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| 摘 要： | 优选了复方烧伤膏的最佳醇提取工艺.以大黄素提取量、干膏率为评价指标,选择乙醇浓度、乙醇用量、提取时间及提取次数为考察因素,利用L9(34)正交实验确定复方烧伤膏的醇提取工艺.结果:最佳提取工艺为加70％的乙醇8倍量,回流提取3次,1h/次.优选出的提取工艺简单、可行,可作为该制剂合理开发的依据.
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| 关 键 词： | 复方烧伤膏 醇提工艺 大黄素 |
| 收稿时间： | 2011/11/30 0:00:00 |
| 修稿时间： | 12/8/2011 4:24:38 PM |
Optimizing alcohol-extraction process for Compound Burn Cream |
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| ZHANG Ya
,
MIAO Shan
,
CAO Wei
,
GUAN Hao
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HU Xiao-long
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LI Xiao-qiang
,
ZHANG Yue
,
HU Da-hai
,
WANG Si-wang.Optimizing alcohol-extraction process for Compound Burn Cream[J].Science Technology and Engineering,2012,12(6):1238-1240. |
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| Authors: | ZHANG Ya MIAO Shan CAO Wei GUAN Hao HU Xiao-long LI Xiao-qiang ZHANG Yue HU Da-hai WANG Si-wang |
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| Institution: | 1 (Institute of Materia Medica,School of Pharmacy1,Department of Burns and Cutaneous Surgery,Xijing Hospital2,the Forth Military Medical University,Xi’an 710032,P.R.China) |
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| Abstract: | The conditions for extraction process of Compound Burn Cream is optimized.Different factors and levels were investigated by orthogonal design with yield of emodin and dried alcohol decocting rated as an index.The primary factors influencing extraction ratio by reflux were the concentration of alcohol,in file refluxing period,the solvent quantity and the times of extraction.The optimal conditions were as follows:refluxing and extracting the medicinal materials for 3 times(1 hours each time) with 8-fold 70% alcohol added.The optimal conditions is used to repeat the alcohol-extraction process three times.The result is the same.So the extraction process is reasonable,simple and able to be used in the production. |
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| Keywords: | compound burn cream alcohol extraction process emodin |
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