血浆置换治疗药物性肝损害临床疗效评价

为探讨血浆置换治疗药物性肝损害的临床疗效，对解放军总医院45例药物性肝损害患者进行79次血浆置换。比较了血浆置换前后患者临床症状、肝肾功能、电解质、凝血酶原活动度、血常规变化等。经血浆置换治疗后，患者临床症状均有不同程度改善，丙氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆红素、直接胆红素、血氨水平较治疗前明显降低（P〈0．05或P〈0．01），凝血酶原活动度明显提高（P〈0．05），无明显不良反应。说明血浆置换治疗药物性肝损害安全、有效。

A Clinical Evaluation of Plasma Exchange in Treatment of Drug-induced Liver Injury

To investigate the therapeutic effect of plasma exchange in drug-induced liver injury. 45 patients with drug-induced liver injury were treated with 79 case-times of plasma exchange. The result of liver function, renal function, electrolyte, prothrombin time activity (PTa), blood routine before and after the treatment were analyzed. After plasma exchange, clinical symptoms of patients with drug-induced liver injury were improved. Alanine tranasaminase and aspartase tranasaminase, total bilirubin, direct bilirubin, blood ammonia obviously decreased (P< 0.05 or P<0.01), PTa obviously increased (P<0.05). There were not obvious side effects during treating. It is concluded that plasma exchange is comparatively effective and safe in treatment of drug-induced liver injury.