| 透明质酸与聚乙二醇单甲醚接枝物的制备和表征 |
| |
| 引用本文： | 殷殿书,元英进.透明质酸与聚乙二醇单甲醚接枝物的制备和表征[J].天津大学学报(自然科学与工程技术版),2005,38(7):565-568. |
| |
| 作者姓名： | 殷殿书 元英进 |
| |
| 作者单位： | 天津大学化工学院 天津300072
(殷殿书)，天津大学化工学院 天津300072(元英进) |
| |
| 基金项目： | 天津市重点自然科学基金资助项目(05YFJZJC01103). |
| |
| 摘 要： | 采用化学桥连法制备了透明质酸与聚乙二醇单甲醚的接枝共聚物(HA-g-MPEG),并对其进行了傅里叶红外光谱(FT-IR)、示差扫描量热仪(DSC)、氢核磁质谱(1HNMR)、碳核磁质谱(13CNMR)分析表征.结果表明:接枝共聚物中透明质酸红外光谱在1640cm-1处的谱带消失,而在1624cm-1处出现酰胺I带,说明连接透明质酸与MPEG反应生成了酰肼键;从DSC分析可知,聚乙二醇连接透明质酸后,链段运动受到限制,晶区结构的规整性下降,导致其熔点降低.1HNMR和13CNMR进一步证实了透明质酸与聚乙二醇的接枝共聚物的生成,并确定了各个峰的归属.
|
| 关 键 词： | 透明质酸 聚乙二醇单甲醚 接枝共聚物 表征 |
| 文章编号： | 0493-2137(2005)07-0565-04 |
| 修稿时间： | 2004年3月5日 |
Synthesis and Characterization of the Graft Copolymer of MPEG into Hyaluronic Acid |
| |
| YIN Dian-shu,YUAN Ying-jin.Synthesis and Characterization of the Graft Copolymer of MPEG into Hyaluronic Acid[J].Journal of Tianjin University(Science and Technology),2005,38(7):565-568. |
| |
| Authors: | YIN Dian-shu YUAN Ying-jin |
| |
| Abstract: | Fourier transform infrared spectroscopy (FT-IR), differential scanning caloremetry (DSC), (hydrogen) nuclear magnetic resonance (~1HNMR), and carbon nuclear magnetic resonance (~(13)CNMR) of graft copolymers of hyaluronic acid with monomethoxyl-polyethylene glycol (HA-g-MPEG) copolymer were (investigated) by using chemical bridging method. The result shows that HA-g-MPEG has amide I band in 1 624 cm~(-1) from FT-IR spectra. It is also illustrated in DSC measurement that the phase change enthalpy of MPEG in HA-g-MPEG decreases because freedom of segment is limited when the MPEG segments are fixed to the HA main chains. ~1HNMR and ~(13)CNMR spectra of HA-g-MPEG are assigned completely. The findings provide a (basis) for studying grafting reaction between HA and MPEG. |
| |
| Keywords: | hyaluronic acid monomethoxyl polyethylene glycol graft copolymer characterization |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
