| 丹皮多糖分离纯化和降血糖作用研究 |
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| 引用本文： | 赵帜平,沈业寿,葛盛芳,胡家菊.丹皮多糖分离纯化和降血糖作用研究[J].安徽大学学报(自然科学版),1999,23(2):90-93. |
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| 作者姓名： | 赵帜平 沈业寿 葛盛芳 胡家菊 |
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| 作者单位： | 安徽大学生命科学学院,合肥,230039 |
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| 基金项目： | 安徽省教育厅科研项目;96JL00142; |
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| 摘 要： | 用芍药科植物牡丹根皮为材料，采用三种不同的方法提取，经ＤＥＡＥ－纤维素ＤＥ－５２离子交换柱纯化，获得丹皮多糖（ＰＳＭ）纯品。动物试验证明，三种不同方法提取ＰＳＭ的纯品，在降血糖活性上有显著差异。蒸馏水浸提得到的纯品ＰＳＭ２ｂ降低血糖率为５９．９％（Ｐ＜０．０１，５０ｍｇ／ｋｇ）和５３．１％（Ｐ＜０．０１，１００ｍｇ／ｋｇ）。温水提取的纯品ＰＳＭ３ｂ降低血糖率为５５．８％（Ｐ＜０．０１，５０ｍｇ／ｋｇ体重）和４５．９％（Ｐ＜０．０５，１００ｍｇ／ｋｇ体重），沸水提取的纯品ＰＳＭ４Ｃ无降血糖活性。
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| 关 键 词： | 丹皮多糖，分离纯化 |
Study on Isolation and Hypoglycemic Activity of Polysaccharide of Mudan Cortex (PSM) of Paeonia Suffruticosa andr |
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| Zhao Zhiping,Shen Yeshou,Ge Shengfang,Hu Jianju.Study on Isolation and Hypoglycemic Activity of Polysaccharide of Mudan Cortex (PSM) of Paeonia Suffruticosa andr[J].Journal of Anhui University(Natural Sciences),1999,23(2):90-93. |
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| Authors: | Zhao Zhiping Shen Yeshou Ge Shengfang Hu Jianju |
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| Institution: | Department of Biology Anhui University Hefei 230039 |
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| Abstract: | Mudan cortex of paeonia
suffrulicosa was extracted with water ( 20-30℃), hot water (40℃) and boiling water (100℃),
treated with ethanol to remove and obtain the crude polysaccharide. Then crude PSM were
purified by DEAE Cellulose DE-52 column to get pure PSM. The laters were given to mice
intraperitoneally. Results showed that PSM extracted with water (20-30℃) and hot water (40℃)
can markedly lower the serum glucose, but PSM extracted with boiling water (100℃) had no
hypoglycemic activity. |
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| Keywords: | polysaccharide of mudan cortex hypoglycemic activity |
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