| 乙交酯丙交酯共聚物电纺丝超细纤维对利福平的控制释放 |
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| 引用本文： | 曾敬,康艳红,苏桂田.乙交酯丙交酯共聚物电纺丝超细纤维对利福平的控制释放[J].沈阳师范大学学报(自然科学版),2011,29(4):537-540. |
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| 作者姓名： | 曾敬 康艳红 苏桂田 |
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| 作者单位： | 沈阳师范大学化学与生命科学学院,沈阳,110034 |
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| 基金项目： | 辽宁省教育厅科学研究资助项目(LS2010154); 沈阳师范大学实验中心主任基金资助项目(SY-200804) |
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| 摘 要： | 载药电纺丝超细纤维体系是药物控制释放领域中一个全新的剂型,近年来已引起广泛的关注.研究了乙交酯丙交酯共聚物(PLGA,LA/GA=80/20)电纺丝超细纤维在磷酸盐缓冲液(pH=7.4)中对利福平的控制释放行为.结果显示利福平的释放过程可分为2个阶段:在第一阶段为释放慢速期,药物的释放速率取决于纤维中利福平分子的扩散速...
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| 关 键 词： | 电纺丝 超细纤维 控制释放 PLGA 利福平 |
Release of Rifampin from poly(lactide-co-glycolide) electrospun fiber mats |
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| ZENG Jing,KANG Yan-hong,SU Gui-tian.Release of Rifampin from poly(lactide-co-glycolide) electrospun fiber mats[J].Journal of Shenyang Normal University: Nat Sci Ed,2011,29(4):537-540. |
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| Authors: | ZENG Jing KANG Yan-hong SU Gui-tian |
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| Institution: | ZENG Jing,KANG Yan-hong,SU Gui-tian (College of Chemistry and Life Science,Shenyang Normal University,Shenyang 110034,China) |
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| Abstract: | Drug-containing electrospun fiber mat is a promising controlled release formulation,and great progress has been made recently.In this article,the release behavior of Rifampin from poly(lactide-co-glycolide)(PLGA,LA/GA=80/20) electrospun fibers in phosphate buffer solution(pH 7.4) was examined.The results showed that the release process of Rifampin is divided into the early stage and the late stage.In the early stage,the drug release is determined by the diffusion of the Rifampin molecules in fibers,and in t... |
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| Keywords: | electrospinning ultrafine fibers controlled release PLGA Rifampin |
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