| 顺铂代谢物[Pt(L-Met-S,N)2]跨细胞膜的吸收 |
| |
| 引用本文： | 魏海英,马玖芬,邵颖,蔡永选,陈艳红.顺铂代谢物[Pt(L-Met-S,N)2]跨细胞膜的吸收[J].河北大学学报(自然科学版),2008,28(5):517. |
| |
| 作者姓名： | 魏海英 马玖芬 邵颖 蔡永选 陈艳红 |
| |
| 作者单位： | 1.河北大学,化学与环境科学学院,河北,保定,071002； 2.绍兴大学,化学系,浙江,绍兴,312000 |
| |
| 基金项目： | 河北省教育厅自然科学基金，河北大学自然科学博士基金 |
| |
| 摘 要： | 对顺铂的主要代谢物Pt(L-Met-S,N)2](Met:蛋氨酸)在Jurkat肿瘤细胞和绵羊红细胞内的跨膜吸收进行了研究,并以顺铂作对照.细胞内铂含量使用等离子体质谱(ICP-MS)测定.结果表明:2种细胞对Pt(L-Met-S,N)2]的吸收曲线趋势一致,但吸收能力要远远低于对顺铂的吸收,这可能与Pt(L-Met-S,N)2]的跨膜机制相关,同时进一步证实Pt(L-Met-S,N)2]没有生物活性.
|
| 关 键 词： | 配合物[Pt(L-Met-S N)2] 顺铂 代谢物 跨膜吸收 |
Cellular Uptake of Cisplatin Metabolite [Pt(L-Met-S,N)2] |
| |
| WEI Hai-ying,MA Jiu-fen,SHAO Ying,CAI Yong-xuan,CHEN Yan-hong.Cellular Uptake of Cisplatin Metabolite [Pt(L-Met-S,N)2][J].Journal of Hebei University (Natural Science Edition),2008,28(5):517. |
| |
| Authors: | WEI Hai-ying MA Jiu-fen SHAO Ying CAI Yong-xuan CHEN Yan-hong |
| |
| Abstract: | The uptake of complex Pt(L-Met-S,N)2] by Jurkat tumor cells and normal sheep red blood cells was carried out in comparison to that of cisplatin.The intracellular Pt content was determined by inductively coupled plasma mass spectrometer(ICP-MS).The experimental results showed that the two cellular uptake curves for complex Pt(L-Met-S,N)2] are consistent.Howerer,the cellular uptake ability of complex Pt(L-Met-S,N)2] is much lower than that of cisplatin.The data confirmed that the biological inactivity of complex Pt(L-Met-S,N)2] in vivo may be relevant to its lower cellular uptake. |
| |
| Keywords: | complex [Pt(L-Met-S N)2] cisplatin metabolite cellular uptake |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《河北大学学报(自然科学版)》浏览原始摘要信息 |
| 点击此处可从《河北大学学报(自然科学版)》下载免费的PDF全文 |
|
