| 流动注射-化学发光法测定药物与体液中的左氧氟沙星 |
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| 引用本文： | 孙汉文,陈雪艳,李丽清,吕运开.流动注射-化学发光法测定药物与体液中的左氧氟沙星[J].河北大学学报(自然科学版),2006,26(2):161-165. |
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| 作者姓名： | 孙汉文 陈雪艳 李丽清 吕运开 |
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| 作者单位： | 1. 河北大学,化学与环境科学学院,河北省分析科学技术实验室,河北,保定,071002
2. 河北大学,化学与环境科学学院,河北省分析科学技术实验室,河北,保定,071002;泰山学院,化学系,山东,泰安,271021 |
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| 基金项目： | 教育部博士点学科基金项目(20050075003) |
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| 摘 要： | 提出了在酸性条件下左氧氟沙星-Ce(Ⅳ)-Na2S2O4化学发光新体系,探讨了该化学发光体系的发光机理.建立了测定左氧氟沙星的流动注射化学发光分析新方法.方法的检出限为7×10-9g/mL,线性范围为2×10-8~6×10-6g/mL,11次平行测定质量浓度为6×10-7g/mL的左氧氟沙星,其相对标准偏差为2.0%.测定了左氧氟沙星注射液和片剂及血清和尿液中左氧氟沙星的含量,回收率为98.4%~103.7%,结果令人满意.
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| 关 键 词： | 化学发光 流动注射 左氧氟沙星 药物 体液 |
| 文章编号： | 1000-1565(2006)02-0161-05 |
| 修稿时间： | 2005年10月26 |
Flow-injection Chemiluminescence Detection for the Determination of Levofloxacin in Pharmaceutical Preparations and Body Fluid |
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| SUN Han-wen,CHEN Xue-yan,LI Li-qing,LU Yun-kai.Flow-injection Chemiluminescence Detection for the Determination of Levofloxacin in Pharmaceutical Preparations and Body Fluid[J].Journal of Hebei University (Natural Science Edition),2006,26(2):161-165. |
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| Authors: | SUN Han-wen CHEN Xue-yan LI Li-qing LU Yun-kai |
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| Abstract: | A new chemiluminescence system,levofloxacin-Ce(Ⅳ)-Na-2S-2O-4-H-2SO-4,was developed for the determination of levofloxacin.The chemiluminescence mechanism of the system was discussed.A new chemiluminescence detection method combined with flow injection was described for the determination of levifloxacin in body fluid and pharmaceutical preparations.The detection limit for levofloxacin is 7×10~(-9) g/mL,and the relative standard deviation(n=11) is 2.0% at 6×10~(-7) g/mL.The linear range is 2×10~(-8)～6×10~(-6) g/mL.The method has been applied to the determination of levofloxacin in body fluid and pharmaceutical preparations with satisfactory results. |
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| Keywords: | chemiluminescence flow injection levofloxacin pharmaceutical preparations body fluid |
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