| 庆大霉素-聚酸酐缓释制剂的制备及释药特性 |
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| 引用本文： | 周志彬,黄开勋,张治国,徐辉碧.庆大霉素-聚酸酐缓释制剂的制备及释药特性[J].华中科技大学学报(自然科学版),2001,29(4):112-113. |
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| 作者姓名： | 周志彬 黄开勋 张治国 徐辉碧 |
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| 作者单位： | 华中科技大学化学系 |
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| 基金项目： | 武汉市科委攻关项目!(996 0 0 5 12 2G) |
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| 摘 要： | 以聚（二聚酸－癸二酸）共取物P(DA-SA),wDA;WSA=50:50]为药物缓释材料，庆大霉素为模型药物，采用热熔法制备庆大霉素－聚酸酐缓释药棒，初步的制剂稳定性研究表明，在室温干燥条件下，该缓释药棒具有良好的制剂稳定性，体外释药结果表明，在37度时质量分数为0．9％的生理盐水体系中，该缓释药棒的体外释药时间为25d，释药动力学符合一级动力学方程，其体外释药程为：Y＝9．1826＋6．690lt-0.1272t2,R2=0.9874，上述结果表明庆大霉素－聚酸酐缓释药棒是一类具有明显缓释作用的释药体系。
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| 关 键 词： | 庆大霉素 聚（二聚酸－癸二酸） 聚酸酐 药物缓慢释放 缓释制剂 释药特性 |
| 文章编号： | 1000-8616(2001)04-0112-02 |
| 修稿时间： | 2000年8月23日 |
Preparation of Gentamicin-polyanhydride and Drug Delivery Property Sustained-release Bead |
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| Zhou Zhibin,Huang Kaixun,Zhang Zhiguo,Xu Huibi.Preparation of Gentamicin-polyanhydride and Drug Delivery Property Sustained-release Bead[J].JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY.NATURE SCIENCE,2001,29(4):112-113. |
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| Authors: | Zhou Zhibin Huang Kaixun Zhang Zhiguo Xu Huibi |
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| Abstract: | A sustained-release bead system consisting of gentamicin dispersed in biodegradable poly (dimmer acid-sebacic acid) copolymer［P(DA-SA), wDA∶wSA=50∶50］ is prepared by melt casting. The stability at room temperature and the in vitro release profile in 0.9% saline buffer at 37℃ of the bead are determined. The result shows that the formulation has a good stability at room temperature under anhydrous conditions for 6 month. The release of gentamicin from the bead can last 25 days, and the drug release behavior in vitro follows the first order release kinetics, and can be expressed as Y=9.1826+6.6901t-0.1272t2, R2=0.9874. All the above show that the gentamicin-polyanhydride sustained-release bead is a significant sustained-release system. |
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| Keywords: | gentamicin poly (dimmer acid sebacic acid) polyanhydride sustained release |
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