| 膜片钳放大器瞬态电流伪差的自动补偿 |
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| 引用本文： | 高刚强,瞿安连.膜片钳放大器瞬态电流伪差的自动补偿[J].华中科技大学学报(自然科学版),2004,32(10):63-65. |
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| 作者姓名： | 高刚强 瞿安连 |
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| 作者单位： | 华中科技大学,生命科学与技术学院,湖北,武汉,430074;华中科技大学,生命科学与技术学院,湖北,武汉,430074 |
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| 基金项目： | 国家自然科学基金资助项目 (30 32 70 0 1) |
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| 摘 要： | 论述了膜片钳放大器中快、慢电容瞬态电流产生的原因和补偿原理，并采用了迭代算法，通过程序控制实现对快、慢电容所引起的瞬态电流伪差进行自动补偿．实验结果表明，该方法能快速有效地补偿快、慢电容瞬态电流，简化了实验操作，提高了实验效率。
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| 关 键 词： | 膜片钳放大器 快电容 慢电容 自动补偿 |
| 文章编号： | 1671-4512(2004)10-0063-03 |
| 修稿时间： | 2004年2月3日 |
Automatic compensation of capacitive transient current in patch-clamp amplifiers |
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| Gao Gangqiang Qu AnlianMaster, College of Life Sci. & Tech.,Huazhong Univ. of Sci. & Tech.,Wuhan ,China..Automatic compensation of capacitive transient current in patch-clamp amplifiers[J].JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY.NATURE SCIENCE,2004,32(10):63-65. |
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| Authors: | Gao Gangqiang Qu AnlianMaster College of Life Sci & Tech Huazhong Univ of Sci & Tech Wuhan China |
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| Institution: | Gao Gangqiang Qu AnlianMaster, College of Life Sci. & Tech.,Huazhong Univ. of Sci. & Tech.,Wuhan 430074,China. |
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| Abstract: | The principle on fast and slow capacitive transient currents and its mechanism were produced; the methods of canceling them were described. Under the procedure controlled, an iterative algorithm was adopted to compensate fast and slow capacitive transient currents automatically. The experimental result showed that this method could compensate the capacitive currents quickly and effectively. The application of the method would save operation time and improve the efficiency of experiments. |
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| Keywords: | patch-clamp amplifier fast capacitance slow capacitance auto transient cancellation |
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