聚丙烯酸、聚乙烯吡咯烷酮对萘普生片释放度的影响

采用自由基溶液聚合方法制得聚乙烯吡咯烷酮（PVP）和聚丙烯酸（PAA）均聚物．将PVP和PAA简单混合制备物理混合物，通过旋转蒸发法制备PAA／PVP复合物，分别以PVP、PAA均聚物、物理混合物、复合物为载体制备药物（以萘普生为模型药物）片剂，采用固体分散技术制备以PAA、PVP为载体的萘普生片．考察这些药片在人工胃液和人工肠液中的释放度，以研究它们输送药物的特性．结果表明：与PVP、PAA均聚物和物理混合物相比，PAA／PVP复合物作为药物载体能使萘普生具有肠溶包衣片的性质；而且提高载体中PAA的比例可使萘普生的释放速率减缓．

Study on PAA and PVP as Drug Delivery Carriers

Poly acrylic acid(PAA) and poly vinyl pyrrolidone(PVP) were obtained by free radical polymerization.Mix PAA and PVP to their physical mixture and prepare the PAA/PVP interpolymer complexes by solvent evaporation method.The naproxen tablets were prepared with PAA,PVP,PAA/PVP mixture and PAA/PVP complexes respectively and also prepared by solid dispersion technique with PAA and PVP.Drug release tests were carried in the stimulated gastric fluid and the stimulated intestine liquid to study the properties of PAA and PVP as drug delivery carriers.It shows that,compared with PVP,PAA homopolymers and physical mixtures,the complexes of PVP and PAA as drug carriers make naproxen have the property of enteric-coated pellets.Additionally,the release rate of naproxen decreases gradually with the amount of PAA increasing.