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| 贵州万山汞矿汞污染生物健康效应 | |
| 引用本文： | 程金平,胡卫萱,马黎,王文华,刘晓洁,瞿丽雅.贵州万山汞矿汞污染生物健康效应[J].上海交通大学学报,2005,39(11):1909-1912. |
| 作者姓名： | 程金平 胡卫萱 马黎 王文华 刘晓洁 瞿丽雅 |
| 作者单位： | 1. 上海交通大学,环境科学与工程学院,上海,200240 2. 日本国立水俣病综合研究所,日本水俣 3. 贵州省环境保护科学研究院,贵阳,550002 |
| 基金项目： | 中国科学院知识创新工程重要方向项目（KZCX3-SW-437）;国家自然科学基金资助项目（20177013）. |
| 摘 要： | 为了探讨贵州万山汞矿汞污染生物健康效应，研究了万山8个月龄鸭子和万山粮食暴露20、30d后大鼠脑、肝、血中MDA、SOD、GSH—px的变化以及大鼠大脑皮层中c-JUN蛋白表达．结果表明：在鸭血清、脑和肝组织中GSH—px和SOD活性与对照组相比均显著升高（P〈0．05），而MDA含量没有发生显著变化（P〉0．05）；万山组大鼠脑、肝、血中MDA、SOD、GSH—px的变化除暴露20dMDA与对照组相比脑组织中含量显著升高（P〈0．05）外，其他均无显著变化（P〉0．05）；大鼠大脑皮层c—JUN蛋白表达显著增加．从而可以推断，硒对汞引起的氧化损伤有很强的保护能力；汞对大鼠脑f—JUN蛋白表达的诱导不是或仅小部分由脂质过氧化所介导． |
| 关 键 词： | 汞污染粮食 氧化损伤 基因表达 健康效应 贵州 |
| 文章编号： | 1006-2467(2005)11-1909-04 |
| 收稿时间： | 2005-03-25 |
| 修稿时间： | 2005年3月25日 |
The Biological Health Effects of Mercury Pollution in Guizhou Wanshan Mercury Mine |
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| CHENG Jin-ping,HU Wei-xuan,MA Li,WANG Wen-hua,LIU Xiao-jie,QU Li-ya.The Biological Health Effects of Mercury Pollution in Guizhou Wanshan Mercury Mine[J].Journal of Shanghai Jiaotong University,2005,39(11):1909-1912. | |
| Authors: | CHENG Jin-ping HU Wei-xuan MA Li WANG Wen-hua LIU Xiao-jie QU Li-ya |
| Institution: | 1. School of Environmental Science and Eng. , Shanghai Jiaotong Univ. , Shanghai 200240, China;2. Ministry of the Environment National Inst. for Minamata Disease, Japan; 3. Guizhou Inst. for Environmental Protection, Guiyang 550002 |
| Abstract: | In order to probe into the biological health effects of mercury pollution in Guizhou Wanshan mercury mine,this paper studied the MDA contents,SOD and GSH-px activities in blood,liver and brain of ducks which were grown on the spot for 8 months and of rats which were exposed to the rice from Guizhou Wanshan mercury mine for 20 d or 30 d.The expression of c-JUN protein in the cortex of rats were observed using immunocytochemical methods.The results show the GSH-px and superoxide dismutase(SOD) activity in blood,liver and brain of the ducks significantly increase compared to the control groups,but MDA content has no significant change;the MDA contents,SOD and GSH-px activities in blood,liver and brain of the rats have no significant change compared to the control groups except the MDA contents in the brain of the rats exposed for 20 d;the expression of c-JUN protein in the cortex of the rats increases significantly.It is concluded that selenium has strong protective capability to the oxidative damage induced by mercury;lipid peroxidation seems not or partially to involve in inducing the expression of c-JUN protein in the process of mercury exposure. |
| Keywords: | mercury contaminated rice oxidative damage gene expression health response Guizhou |
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