| 聚乙二醇对尼莫地平溶解性能的影响 |
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| 引用本文： | 郭圣荣,张芳,张亚琼,郭丽,赵凤生.聚乙二醇对尼莫地平溶解性能的影响[J].上海交通大学学报,2004,38(2):312-315. |
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| 作者姓名： | 郭圣荣 张芳 张亚琼 郭丽 赵凤生 |
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| 作者单位： | 上海交通大学,药学院,上海,200030 |
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| 摘 要： | 测定了尼莫地平(nimodipine，NM)在聚乙二醇(PEG)的磷酸缓冲溶液中的溶解度；用熔融法制备了NM-PEG-6000固体分散体(SD)；由差热分析(DSC)和X射线衍射(XRD)分析鉴剐药物在载体中的存在状态，并进行体外溶出度测定．结果表明，随PEG浓度增大，NM的溶解度增大；NM以微细结晶存在于PEG中；随着SD内PEG比例的增大，NM的释药速率明显增大，而且2h的累积溶出度也增大。因此，PEG对NM有增溶作用；NM-PEG-6000固体分散体和物理混合物可提高药物的溶出速率。
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| 关 键 词： | 尼莫地平 聚乙二醇-6000 溶出度 固体分散体 |
| 文章编号： | 1006-2467(2004)02-0312-04 |
| 修稿时间： | 2002年12月13 |
The Effects of PEG on the Solubility of Nimodipine |
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| GUO Sheng-rong,ZHANG Fang,ZHANG Ya-qiong,GUO Li,ZHAO Feng-sheng.The Effects of PEG on the Solubility of Nimodipine[J].Journal of Shanghai Jiaotong University,2004,38(2):312-315. |
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| Authors: | GUO Sheng-rong ZHANG Fang ZHANG Ya-qiong GUO Li ZHAO Feng-sheng |
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| Abstract: | The nimodipine(NM) solid dispersions(SD) were prepared by solvent-melting; DSC and X-ray powder diffractometry were used to determine the status of NM in carriers, and in vitro dissolution characteristics were studied. The results show that the solubility of NM increases with the PEG concentration; the drug in solid dispersions exists in microcrystalline form; the dissolutions of the solid dispersions are much more than that of the pure drug. |
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| Keywords: | nimodipine (NM) polyethylene glycols (PEG)-6000 dissolution solid dispersion |
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