| 壳聚糖/海藻酸钠水凝胶的制备及其在药物控释中的应用 |
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| 引用本文： | 郑学芳,刘纯,廉琪,贾丹丹,田宏燕,王东军.壳聚糖/海藻酸钠水凝胶的制备及其在药物控释中的应用[J].河北科技师范学院学报,2010,24(1):8-11. |
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| 作者姓名： | 郑学芳 刘纯 廉琪 贾丹丹 田宏燕 王东军 |
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| 作者单位： | 河北科技师范学院,理化学院,河北,秦皇岛,066600 |
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| 基金项目： | 河北省自然科学基金资助项目 |
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| 摘 要： | 以戊二醛(GA)为交联剂,壳聚糖作为聚阳离子组分,海藻酸钠作为聚阴离子组分,制备了壳聚糖(CS)海藻酸钠(SA)水凝胶。探讨了改变溶液的pH值和交联剂用量等条件对两种水凝胶溶胀性能的影响。交联剂含量、pH对CS-SA水凝胶溶胀率的影响较大,且在酸性条件下的水凝胶的溶胀率远大于碱性条件下的溶胀率,包埋在此水凝胶中的牛血清蛋白(BSA)释放随载药介质的pH值的变化而显著不同,pH值为1.0条件下载药的水凝胶释药率大于pH值为7.4,9.18条件下的释药率。
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| 关 键 词： | 壳聚糖 海藻酸钠 牛血清蛋白 控制释放 |
Preparation of Chitosan/Alginate Hydrogels and its Application in Drug Controlled Release |
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| ZHENG Xue-fang,LIU Chun,LIAN Qi,JIA Dan-dan,TIAN Hong-yan,WANG Dong-jun.Preparation of Chitosan/Alginate Hydrogels and its Application in Drug Controlled Release[J].Journal of Hebei Normal University of Science & Technology,2010,24(1):8-11. |
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| Authors: | ZHENG Xue-fang LIU Chun LIAN Qi JIA Dan-dan TIAN Hong-yan WANG Dong-jun |
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| Institution: | (College of Physics ＆ Chemistry,Hebei Normal University of Science ＆ Technology,Qinhuangdao Heibei,066600,China) |
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| Abstract: | pH-sensitive hydrogels based on chitosan-sodium alginate（CS-SA） was synthesized by using glutaradehyde as cross-link agent.The effects of the degree of the dosage of crosslinking and pH on the swelling behaviors of the hydrogel were studied.The results showed that the swelling ratio（SR） of this hydrogel in acide solution was much larger than that in alkaline solution.The release behavior of bovine serum alumin entrapped in the hydrogels was of distinct difference with the changes of pH value of loading medium.The release of bovine serum alumin in the two kinds of hydrogels in the medium of pH 1.0 was much quicker than that in pH 7.4 and 9.18. |
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| Keywords: | chitosan sodium alginate bovine serum albumin controlled release |
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