| 噬菌体展示肽库技术及其在分子病原细菌学研究中的应用 |
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| 引用本文： | 赵红蕾,刁昱文,冯新,高宇,刘珊珊,顾敬敏,雷连成,韩文瑜.噬菌体展示肽库技术及其在分子病原细菌学研究中的应用[J].河北科技师范学院学报,2011,25(1):34-38. |
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| 作者姓名： | 赵红蕾 刁昱文 冯新 高宇 刘珊珊 顾敬敏 雷连成 韩文瑜 |
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| 作者单位： | 吉林大学畜牧兽医学院,吉林长春,130062 |
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| 摘 要： | 从噬菌体展示技术的基本原理、肽库的构建、噬菌体肽库的分类、噬菌体肽库的筛选方法等方面,综述了噬菌体展示肽库技术;从抗原表位研究、免疫诊断研究、基因疫苗研究、抗菌药物的靶向投递等方面,阐述了噬菌体展示肽库技术在分子病原细菌学中的应用;并对今后的研究方向进行了展望.
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| 关 键 词： | 噬菌体展示肽库 病原细菌学 应用 |
Phage Display Peptide Library and Its Research in Molecular Bacteriology of Pathogenic |
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| ZHAO Hong-lei,DIAO Yu-wen,FENG Xin,GAO Yu,LIU Shan-shan,GU Jing-min,LEI Lian-cheng,HAN Wen-yu.Phage Display Peptide Library and Its Research in Molecular Bacteriology of Pathogenic[J].Journal of Hebei Normal University of Science & Technology,2011,25(1):34-38. |
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| Authors: | ZHAO Hong-lei DIAO Yu-wen FENG Xin GAO Yu LIU Shan-shan GU Jing-min LEI Lian-cheng HAN Wen-yu |
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| Institution: | (College of Animal Science and Veterinary Medicine,Jilin University,Changchun Jilin,130062,China) |
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| Abstract: | This paper reviewed the phage display peptide library technique from the basic principle of phage display,the construction and classification of phage peptide library,and the screening methods;the paper also explained the application of phage display peptide library technology in molecular pathogenic bacteriology from antigen epitopes,immune diagnosis,genetic vaccine research,and targeted delivery of antibiotics;future research directions were also introduced in the end. |
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| Keywords: | phage display peptide library pathogenic bacteriology application |
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