| 红霉素与DNA相互作用的电化学研究 |
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| 引用本文： | 廖天录,赵强.红霉素与DNA相互作用的电化学研究[J].大庆师范学院学报,2011(6):45-47. |
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| 作者姓名： | 廖天录 赵强 |
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| 作者单位： | 甘肃工业职业技术学院化工学院; |
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| 摘 要： | 采用循环伏安法和交流阻抗技术研究了药物红霉素分子与DNA的相互作用。实验表明,红霉素在DNA修饰玻碳电极上有较强烈的吸附,可以与DNA发生相互作用,其作用模式为嵌入模式;通过交流阻抗技术,研究了红霉素在DNA修饰玻碳电极表面与DNA作用的表观异相电子转移速率常数kf,其结果与循环伏安实验的研究结论一致。通过该实验可以对红霉素的药物学性质以及药理作用提供理论依据。
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| 关 键 词： | 红霉素 DNA修饰电极 循环伏安法 交流阻抗法 玻碳电极 |
Electrochemical Studies of Erythromycin and Interaction with DNA |
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| LIAO Tian-lu,ZHAO-Qiang.Electrochemical Studies of Erythromycin and Interaction with DNA[J].Journal of Daqing Normal University,2011(6):45-47. |
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| Authors: | LIAO Tian-lu ZHAO-Qiang |
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| Institution: | LIAO Tian-lu,ZHAO-Qiang(Department of Chemistry Engineering,Gansu Industry Polytechnic College,Tianshu 741025,China) |
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| Abstract: | we report here the studies on the binding of ERM to DNA by surface electrochemical methods,DNA modified electrode.Using cyclic voltammetry(CV),A.C.impedance and determined the electrochemical parameters.The results shown that ERM can bind to DNA at DNA modified glass carbon electrode.By A.C.impedance,kf from A.C.impedance were obtained.The results provide new insight into rational drug design and would lead us to further understanding of the interaction mechanism between antitumour drug and DNA. |
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| Keywords: | erythromycin(ERM) DNA-modified electrode cyclic voltammetry A C impedance methods glassy carbon electrode |
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