红树林内生真菌K38和E33混合发酵代谢产物研究

将混合发酵技术应用于来自南海红树林内生真菌E33和K38的培养,其发酵液乙酸乙酯萃取物对多种植物病原菌有较强抑制活性,从该提取物中分离到deoxyscytalidin(1),1-甲氧基-2-羟基-3-甲基蒽醌(2),5-丁基-2-吡啶甲酸甲酯(3),5-(3-丁烯基)-2-吡啶甲酸甲酯(4),sescandelin(5)五个单独培养未能得到的代谢产物,其中化合物1,2,3,4为首次从海洋真菌里得到。

Studies on Metabolites from the Mixed Fermentation Products of Two Mangrove Endophytic Fungi K38 and E33

The technique of mixed fermentation was applied to culture two mangrove endophytic fungi K38 and E33 from the South China Sea Coast. The crude extracts from the fermentation liquids extracted by ethyl acetate showed significant inhibitory activities to several plant pathogens. Five secondary metabolites were isolated from this crude extracts, which did not obtained from these two strains by pure fermentation before. Their structures were elucidated by spectral methods to be deoxyscytalidin（1），2-hydroxy-1-methoxy-3-methylanthracene-9,10-dione(2)，methyl 5 butylpicolinate(3)，methyl 5 (but 3 enyl)picolinate(4)，sescandelin（5）. Compound 1,2,3,4 were found in marine fungi for the first time.