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| 广东凉茶颗粒苷类化学成分研究 | |
| 引用本文： | 王志芳,符崖,向俊,黄兆胜,张中强,宋化灿,钟莹,张翠仙.广东凉茶颗粒苷类化学成分研究[J].中山大学学报(自然科学版),2013,52(2):79-83. |
| 作者姓名： | 王志芳 符崖 向俊 黄兆胜 张中强 宋化灿 钟莹 张翠仙 |
| 作者单位： | 1. 广州中医药大学中药学院,广东 广州,510006 2. 广州中医药大学第二附属医院,广东 广州,510120 3. 中国广州分析测试中心广东省分析测试技术公共实验室,广东 广州,510070 |
| 基金项目： | 广东省科技计划重点资助项目(2010A03010003):广东省分析测试技术公共实验室开放课题资助项目 |
| 摘 要： | 为进一步阐明广东凉茶颗粒的药效物质基础和完善其质量标准,首次对其化学成分进行系统研究。从其甲醇提取物的乙酸乙酯部位分离得到5个苷类成分,采用物理常数对照和现代波谱分析方法确定其结构依次为:4-p-香豆酸-D-吡喃葡萄糖苷(1)、2α,3α,19α-三羟基乌苏-12-烯-28-酸28-O-β-D-吡喃葡萄糖苷(2)、2α,3β,19α-三羟基乌苏-12-烯-28-酸28-O-β-D-吡喃葡萄糖(3)、2α,3β,19α,23-四羟基乌苏-12-烯-28-酸28-O-β-D-吡喃葡萄糖苷(4)、木犀草素-6-C-葡萄糖苷(5)。1为首次得到的天然产物,1,2,3,4,5均首次从广东凉茶颗粒中分离得到,为进一步研究其药效及药理活性打下基础。 |
| 关 键 词： | 广东凉茶颗粒 物质基础 苷类 |
| 收稿时间： | 2012-10-09; |
Analysis of Chemical Constituents of Guangdong Liangcha |
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| WANG Zhifang , FU Ya , XIANG Jun , HUANG Zhaosheng , ZHANG Zhongqiang , SONG Huacan , ZHONG Ying , ZHANG Cuixian.Analysis of Chemical Constituents of Guangdong Liangcha[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2013,52(2):79-83. | |
| Authors: | WANG Zhifang FU Ya XIANG Jun HUANG Zhaosheng ZHANG Zhongqiang SONG Huacan ZHONG Ying ZHANG Cuixian |
| Institution: | (1. School of Chinese Materical Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; 2. The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510120； 3. Guangdong Provincial Public Laboratory of Analysis and Testing Technology, China National Analytical Center of Guangzhou, Guangzhou 510070, China) |
| Abstract: | In order to analyze chemical constituents and quality standard of Guangdong Liangcha, five glycosides were isolated. Their structures were determined to be 4-p- cumaroyl-D- glucose (1), 2α, 3α, 19α-trihydroxyursa-12-en--28-oic acid β-D-glucopyranosyl ester (2), 2α, 3β, 19α-trihydroxyursa-12-en-28-oic acid β-D-glucopyranosyl ester (3), 2α, 3β, 19α, 23- tetrahydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester (4), 6-C-glycopyr- anosyl luteolin (5) by spectroscopic analysis. Compound 1 was firstly obtained as a natural product, and compounds 1,2,3,4,5 were also firstly obtained from Guangdong Liangcha, which was contributed to further mechanism of bioactivity. |
| Keywords: | Guangdong Liangcha chemical constituents glycosides |
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