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角蒿中的环己乙醇类化学成分研究
引用本文:李钦,沈月毛,张评浒,张陆勇,李萍.角蒿中的环己乙醇类化学成分研究[J].中山大学学报(自然科学版),2008,47(5).
作者姓名:李钦  沈月毛  张评浒  张陆勇  李萍
作者单位:1. 中国药科大学现代中药教育部重点实验室,江苏,南京,210009;中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南,昆明,650204
2. 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南,昆明,650204
3. 中国药科大学新药筛选中心,江苏,南京,210009
4. 中国药科大学现代中药教育部重点实验室,江苏,南京,210009
基金项目:国家自然科学基金,国家自然科学基金
摘    要: 利用Sephadex LH-20及硅胶等柱色谱技术从药用民族植物角蒿(Incarvillea dissectifoliolaQ.S. Zhao)的根茎中分离得到了11个环己乙醇类化合物。经理化数据对照和波谱分析,确定它们的结构分别为rengyolone(1), (3aS, 6R) 2,3,3a,6,7,7a-hexahydrobenzofuran-3a,6-diol (2),(3aR)-hexahydro-3ahydroxybenzofuran-6(2H)-one(3),(3aR,6R)-octahydrobenzofuran-3a,6-diol (4),(3aR,6S)-octahydrobenzofuran-3a,6-diol (5),4-hydroxy-4-(2-hydroxyethyl) cyclohexanone (6),(3aS,4S)-hexahydro-3a,4-dihydroxybenzofuran-6(2H)-one (7),(3aR,4S)-hexahydro-3a,4-dihydroxy benzofuran-6(2H)-one (8),rengyol (9),isorengyol (10)和rengyoside B (11)。这11个化合物均为首次从角蒿中分离得到。化合物4,5,6,7,8,9,10的细胞毒活性未见报道,对它们的细胞毒活性进行了测定,结果表明它们对HL-60细胞株的IC50分别为102,44.7,24.6,98.0,47.8,25.3,92.3和47.2 μmol/L。

关 键 词:角蒿  环己乙醇  化学成分  细胞毒实验
收稿时间:2008-03-28;

Cyclohexylethanoids from Incarvillea dissectifoliola Q.S. Zhao
LI Qin,SHEN Yue-mao,ZHANG Ping-hu,ZHANG Lu-yong,LI Ping.Cyclohexylethanoids from Incarvillea dissectifoliola Q.S. Zhao[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2008,47(5).
Authors:LI Qin  SHEN Yue-mao  ZHANG Ping-hu  ZHANG Lu-yong  LI Ping
Institution:(1. Key Laboratory of Modern Chinese Medicines and Department of Pharmacognosy,China Pharmaceutical University,Nanjing 210009,China;2.State Key Laboratory of Phytochemistry and Plant Resources in West China,Kun ming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China;3.New Drug Screening Center,China Pharmaceutical University,Nanjing 210009,China)
Abstract:Eleven compounds were isolated and purified from the roots of Incarvillea dissectifoliola QS Zhao by silica gel and Sephadex LH-20 column chromatography. On the basis of spectroscopic evidences and physiochemical properties,their structures were identified as rengyolone(1), (3aS, 6R)-2,3,3a,6,7,7a-hexahydrobenzofuran-3a,6-diol (2),(3aR)-hexahydro-3a hydroxybenzofuran-6(2H)-one(3),(3aR,6R)-octahydrobenzofuran-3a,6-diol (4),(3aR,6S)-octahydrobenzofuran-3a,6-diol (5),4-hydroxy-4- (2-hydroxyethyl) cyclohexanone (6),(3aS,4S)-hexahydro-3a,4-dihydroxybenzofuran-6(2H)-one (7),(3aR,4S)-hexahydro-3a,4-dihydroxy benzofuran-6(2H)-one (8),rengyol (9),isorengyol (10) and rengyoside B (11). All compounds are isolated from the plant for the first time. Compounds 4,5,6,7,8,9,10,11showed somewhat cytotoxicity against HL-60 cell line in vitro with IC50 valves of 102,44.7,24.6,98.0,47.8,25.3,92.3 and 47.2 μmol/L,respectively.
Keywords:Incarvillea dissectifoliola QSZhao  cyclohexylethanoids  chemical constituents  cytotoxicity testing
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