| 聚氨酯中心静脉导管表面接枝聚维酮碘及抗菌性能研究 |
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| 引用本文： | 陈翠,丁侃贤,李志云,庞来兴,祝方明.聚氨酯中心静脉导管表面接枝聚维酮碘及抗菌性能研究[J].中山大学学报(自然科学版),2012,51(5):26-30. |
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| 作者姓名： | 陈翠 丁侃贤 李志云 庞来兴 祝方明 |
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| 作者单位： | 中山大学化学与化学工程学院,广东广州,510275 |
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| 基金项目： | 广东省-教育部产学研结合资助项目(2008B090500188) |
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| 摘 要： | 利用紫外光接枝技术,在聚氨酯中心静脉导管表面接枝聚乙烯基吡咯烷酮(聚维酮,PVP),再与碘络合,得到表面接枝聚维酮碘(PVP-I)的改性聚氨酯中心静脉导管(PU-g-PVP-I).将这种表面改性的中心静脉导管加到同样体积的液体培养基中,分别接种大肠杆菌、金黄色葡萄球菌、白色葡萄球菌和蜡状芽孢杆菌四种菌体,恒温培养15 ～ 18 h后得到抗菌性能曲线；结果表明,PU-g-PVP-I具有持久、广谱、高效的抗菌作用.
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| 关 键 词： | 聚维酮碘 聚氨酯中心静脉导管 接枝聚合 广谱抗菌性能 |
| 收稿时间： | 2012-04-17; |
The Grafting of Povidone Iodine onto the Surface of Polyurethane Central Venous Catheter and the Anti-bacterial Properties Study |
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| CHEN Cui
,
DING Kanxian
,
LI Zhiyun
,
PANG Laixing
,
ZHU Fangming.The Grafting of Povidone Iodine onto the Surface of Polyurethane Central Venous Catheter and the Anti-bacterial Properties Study[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2012,51(5):26-30. |
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| Authors: | CHEN Cui DING Kanxian LI Zhiyun PANG Laixing ZHU Fangming |
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| Institution: | (College of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,China) |
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| Abstract: | Polyvinylpyrrolidone (PVP) was grafted onto the surface of polyurethane central venous catheter with the UV grafting technology, and then the grafted PVP was complexed with iodine (I2) in ethanol to yield povidone iodine. In order to investigate the anti-bacterial property, the surface-modified catheter was put into the nutrient broth with the same volume in which Escherichia coli, Staphylococcus aureus, Staphylococcus albus, and Bacillus cereus were inoculated，respectively. The results show that the surface-modified central venous catheter has the anti-bacterial effect of long-lasting, broad-spectrum and high-efficiency. |
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