| 布洛酚-邻氨基苯酚衍生物的合成及酪氨酸酶催化的释放研究 |
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| 引用本文： | 徐迪,黄成红,黄仲立,马林,古练权.布洛酚-邻氨基苯酚衍生物的合成及酪氨酸酶催化的释放研究[J].中山大学学报(自然科学版),2006,45(3):54-57. |
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| 作者姓名： | 徐迪 黄成红 黄仲立 马林 古练权 |
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| 作者单位： | 中山大学化学与化学工程学院,广东,广州,510275 |
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| 摘 要： | 设计并合成了邻氨基酚布洛酚酯,根据推论的酪氨酸酶催化反应机理,进行了模拟实验研究。邻氨基酚布洛酚酯在酪氨酸酶和芳香胺存在下,发生了氧化、加成和取代反应,实现了布洛酚的释放,表明该设计在黑色瘤治疗中的潜在应用前景。
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| 关 键 词： | 酪氨酸酶 邻氨基酚 布洛酚 |
| 文章编号： | 0529-6579（2006）03-0054-04 |
| 收稿时间： | 2005-08-02 |
| 修稿时间： | 2005年8月2日 |
Model Prodrug for Treatment of Malignant Melanoma: Designed and Synthesis of o-Aminophenol Derivative |
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| XU Di,HUANG Cheng-hong,HUANG Zhong-li,MA Lin,GU Lian-quan.Model Prodrug for Treatment of Malignant Melanoma: Designed and Synthesis of o-Aminophenol Derivative[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2006,45(3):54-57. |
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| Authors: | XU Di HUANG Cheng-hong HUANG Zhong-li MA Lin GU Lian-quan |
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| Institution: | School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 ,China |
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| Abstract: | A novel model prodrug of o-aminophenol derivative was designed and synthesized and functioned as a tyrosinase substrate to allow treatment of malignant melanoma.After being catalyzed by tyrosinase and aromatic amine,the reaction product and HPLC analysis indicate that this agent has been evaluated for tyrosinase-mediated drug release,and shown to act in the desired manner. |
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| Keywords: | tyrosinase o-aminophenol ibuprofen |
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