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奥硝唑注射液过敏试验研究
引用本文:王春梅,张成义,范新田,孔繁利.奥硝唑注射液过敏试验研究[J].北华大学学报(自然科学版),2001,2(5):382-383.
作者姓名:王春梅  张成义  范新田  孔繁利
作者单位:北华大学,医学院,吉林,吉林,132001
基金项目:中华医学基金会资助项目;第9904号;
摘    要:目的 通过连续全身给药,观察豚鼠全身超敏反应。方法 豚鼠36只,分3组,每组12只,分别给0.2%奥硝唑注射液,0.9%生理盐水,5%卵清蛋白致敏,每d0.5mL,共注射3次,间日给药,每组随机均分2批,第1批致敏后14d,第2批致敏后21d进行攻击。结果 攻击后15min内,除5%卵清蛋白致敏组外,均未见超敏反应发生。结论 0.2%奥硝唑注射液对豚鼠未产生全身超敏反应。

关 键 词:超敏反应  奥硝唑  豚鼠  注射液  抗感染药物  机体免疫系统  反应级数
文章编号:1009-4822(2001)05-0382-02
修稿时间:2001年5月16日

Study of Ornidazole on Allergic Experiment
Wang Chunmei,Zhang Chengyi,Fan Xintian,Kong Fanli.Study of Ornidazole on Allergic Experiment[J].Journal of Beihua University(Natural Science),2001,2(5):382-383.
Authors:Wang Chunmei  Zhang Chengyi  Fan Xintian  Kong Fanli
Abstract:Objective To observe the allergic reaction of guinea pigs to consecutive administration of ornidazole.Methods Thirty six guinea pigs were divided into three groups equally and given 0.2% ornidazole,0.9% saline and 0.5% egg white to each respectively three times every other day.Each group was divided into two subgroups randomly,and they were attacked on the 14th and 21st day after sensitization.Results During 15 minutes after attacking,there were no allergic reaction occured in guinea pigs except 5% egg white group.Conclusion 0.2% Ornidazole injection can't induce allergic reaction in guinea pigs.
Keywords:Allergic reaction  Sensitization  Ornidazole  Guinea pig  
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