阿托伐他汀联合氯吡格雷对急性脑梗死患者颈动脉粥样硬化斑块及凝血功能的影响

目的探讨阿托伐他汀联合氯吡格雷治疗对急性脑梗死患者颈动脉粥样硬化斑块及凝血功能的影响.方法将80例急性脑梗死患者根据随机数字法分为对照组(阿司匹林及阿托伐他汀)和观察组(对照组基础上,加用氯吡格雷),比较两组治疗的临床疗效、治疗前后动脉粥样硬化斑块面积及颈动脉中层厚度,治疗前后凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)水平变化情况.结果与对照组相比,观察组治疗的总有效率明显增高(P0.05);与对照组相比,观察组治疗后动脉粥样硬化斑块面积及颈动脉中层厚度均明显减少(P0.05);与对照组相比,观察组治疗后PT,APTT均明显增高,FIB水平显著降低(P0.05).结论阿托伐他汀联合氯吡格雷治疗能够明显减少急性脑梗死患者的斑块面积,改善凝血指标,提高疗效,值得临床推广使用.

Effects of Atorvastatin Combined with Clopidogrel on Carotid Atherosclerotic Plaque and Coagulation Function in Patients with Acute Cerebral Infarction

Objective To explore the effects of atorvastatin combined with clopidogrel on carotid atherosclerotic plaque and coagulation function in patients with acute cerebral infarction. Method A total of 80 patients with acute cerebral infarction were randomized into the control group ( aspirin and atorvastatin ) and the observation group ( based on the control group,addition of clopidogrel) according to the random number method. The clinical efficacy of the treatment,atherosclerosis plaque area and carotid intima-media thickness ( IMT) on pre-treatment and post-treatment,the level change of prothrombin time (PT),activated partial thromboplastin time (APTT), fibrinogen ( FIB) on pre-treatment and post-treatment in the two groups were compared. Results Compared with the control group, the total effective rate of the treatment significantly increased in the observation group (P<0. 05),the atherosclerosis plaque area and IMT on post-treatment obviously decreased (P<0. 05),the levels of PT and APTT significantly increased and the level of FIB obviously decreased on post-treatment (P<0. 05). Conclusion The treatment of atorvastatin combined with clopidogrel can significantly reduce the atherosclerosis plaque area for patients with acute cerebral infarction,improve the coagulation indicators and increase the clinical efficacy,and is worthy of clinical promotion.